Recent advances in the treatment of non-alcoholic fatty liver disease

Flavia D. Mendes, Keith D. Lindor

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Non-alcoholic steatohepatitis is a liver disease strongly associated with features of the metabolic syndrome. It is part of the disease spectrum of non-alcoholic fatty liver disease, which is now thought to be the most common cause of chronic liver disease in the US and other Western countries. Initially this condition was considered innocuous but it is now recognised as having the potential to progress to cirrhosis and its complications. The role of insulin resistance and oxidative stress in its pathogenesis is increasingly accepted. Current investigations are directed towards a better understanding of the natural history, pathogenesis and development of treatment strategies. Several therapeutic modalities, including antioxidants, insulin-sensitising agents and lipid-lowering agents, have been evaluated for the treatment of these patients, mostly in small clinical trials. Despite promising results, no therapy has demonstrated a proven benefit.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalExpert Opinion on Investigational Drugs
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Keywords

  • Drug therapy
  • Fatty liver
  • Non-alcoholic steatohepatitis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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