TY - JOUR
T1 - Recent Advances in Nanoencapsulation of Phytochemicals to Combat Obesity and Its Comorbidities
AU - Goktas, Zeynep
AU - Zu, Yujiao
AU - Abbasi, Mehrnaz
AU - Galyean, Shannon
AU - Wu, Dayong
AU - Fan, Zhaoyang
AU - Wang, Shu
N1 - Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/8/5
Y1 - 2020/8/5
N2 - An increasing epidemic of obesity has become a serious public health concern primarily because it contributes to pathogenesis of many chronic diseases including type 2 diabetes, cardiovascular disease, hepatobiliary disease, obstructive sleep apnea, kidney disease, some types of cancer, among others. Consumption of a variety of phytochemicals has emerged as a promising potential for combating obesity and its comorbidities. However, the generally low aqueous solubility, stability, bioavailability, and target specificity of phytochemicals, along with their side-effects and toxicity seen when used at high doses, have restricted their clinical applications. As a solution, phytochemicals can be encapsulated into nanoparticles to increase their stability and solubility, enhance their bioavailability, protect them from premature degradation in the body, prolong their circulation time, and thus enhance their antiobesity activity. In this perspective, we summarize the problems and limitations of the prominent phytochemicals (epigallocatechin gallate, trans-resveratrol, curcumin, and quercetin), the major biocompatible and biodegradable nanoparticles, and the efficacy of nanoencapsulated forms of these phytochemicals in combating obesity and its comorbidities.
AB - An increasing epidemic of obesity has become a serious public health concern primarily because it contributes to pathogenesis of many chronic diseases including type 2 diabetes, cardiovascular disease, hepatobiliary disease, obstructive sleep apnea, kidney disease, some types of cancer, among others. Consumption of a variety of phytochemicals has emerged as a promising potential for combating obesity and its comorbidities. However, the generally low aqueous solubility, stability, bioavailability, and target specificity of phytochemicals, along with their side-effects and toxicity seen when used at high doses, have restricted their clinical applications. As a solution, phytochemicals can be encapsulated into nanoparticles to increase their stability and solubility, enhance their bioavailability, protect them from premature degradation in the body, prolong their circulation time, and thus enhance their antiobesity activity. In this perspective, we summarize the problems and limitations of the prominent phytochemicals (epigallocatechin gallate, trans-resveratrol, curcumin, and quercetin), the major biocompatible and biodegradable nanoparticles, and the efficacy of nanoencapsulated forms of these phytochemicals in combating obesity and its comorbidities.
KW - curcumin
KW - epigallocatechin gallate
KW - nanoparticles
KW - obesity
KW - quercetin
KW - trans-resveratrol
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U2 - 10.1021/acs.jafc.0c00131
DO - 10.1021/acs.jafc.0c00131
M3 - Review article
C2 - 32633507
AN - SCOPUS:85089616167
SN - 0021-8561
VL - 68
SP - 8119
EP - 8131
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 31
ER -