Reaction of the avian respiratory system to intratracheally administered avirulent Salmonella typhimurium.

T. E. Toth, R. Curtiss, H. Veit, R. H. Pyle, P. B. Siegel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Chickens were inoculated intratracheally (IT) with the SR-11 Salmonella typhimurium deletion mutant x4062 strain. Data collected for 8 days postinoculation (PI) were: signs of respiratory and gastrointestinal disease; histological lesions; the influx, phagocytic proportion, and phagocytic capacity of avian respiratory phagocytes (ARPs); and the proportion of granulocytes vs. macrophages in the lung tissues and lavage fluids of the lungs and air sacs. S. typhimurium-inoculated chickens had no clinical signs of gastrointestinal or respiratory disease but had various degrees of inflammatory changes in the lungs. At 5 hr PI, S. typhimurium-inoculated chickens had approximately 53-fold more ARPs than mock-inoculated controls. Between 26 hr and 8 days PI, the number of ARPs from S. typhimurium-inoculated birds was not significantly higher than the number from the mock-inoculated controls. Flow cytometric analysis of ARPs demonstrated that the proportion of phagocytic ARPs and the phagocytic capacity of ARPs from S. typhimurium-inoculated chickens were significantly higher between 5 and 26 hr PI than those of the ARPs from mock-inoculated chickens. Kinetic changes over 8 days in the granulocyte/macrophage ratios in the lavage fluids, as compared with kinetic changes in the lung tissues, suggested that the granulocytes generally represent a much higher proportion of the ARPs, and egress earlier and in much larger numbers from the tissues to the lumen of lungs and air sacs than do macrophages.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalAvian Diseases
Volume36
Issue number1
StatePublished - Jan 1992
Externally publishedYes

Fingerprint

phagocytes
Salmonella typhimurium
Phagocytes
respiratory system
Salmonella Typhimurium
Respiratory System
Chickens
lungs
chickens
granulocytes
Granulocytes
Air Sacs
Lung
air sacs
macrophages
Macrophages
digestive system diseases
respiratory tract diseases
kinetics
Gastrointestinal Diseases

ASJC Scopus subject areas

  • Cancer Research
  • Immunology
  • veterinary(all)

Cite this

Toth, T. E., Curtiss, R., Veit, H., Pyle, R. H., & Siegel, P. B. (1992). Reaction of the avian respiratory system to intratracheally administered avirulent Salmonella typhimurium. Avian Diseases, 36(1), 24-29.

Reaction of the avian respiratory system to intratracheally administered avirulent Salmonella typhimurium. / Toth, T. E.; Curtiss, R.; Veit, H.; Pyle, R. H.; Siegel, P. B.

In: Avian Diseases, Vol. 36, No. 1, 01.1992, p. 24-29.

Research output: Contribution to journalArticle

Toth, TE, Curtiss, R, Veit, H, Pyle, RH & Siegel, PB 1992, 'Reaction of the avian respiratory system to intratracheally administered avirulent Salmonella typhimurium.', Avian Diseases, vol. 36, no. 1, pp. 24-29.
Toth, T. E. ; Curtiss, R. ; Veit, H. ; Pyle, R. H. ; Siegel, P. B. / Reaction of the avian respiratory system to intratracheally administered avirulent Salmonella typhimurium. In: Avian Diseases. 1992 ; Vol. 36, No. 1. pp. 24-29.
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