Rapid Soft Tissue Approximation and Repair Using Laser-Activated Silk Nanosealants

Russell Urie, Chengchen Guo, Deepanjan Ghosh, Mitzi Thelakkaden, Valerie Wong, Jung Keun Lee, Jacquelyn Kilbourne, Jeffery Yarger, Kaushal Rege

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Tissue approximation and repair are conventionally performed with sutures and staples, but these means are inherently traumatic. Tissue approximation using laser-responsive nanomaterials can lead to rapid tissue sealing and repair, and is an attractive alternative to existing clinical methods. Here, the use of laser-activated nanosealants (LANS) with gold nanorods (GNRs) embedded in silk fibroin polypeptide matrices is demonstrated. The adaptability of LANS for sealing soft tissues is demonstrated using two different modalities: insoluble thin films for internal, intestinal tissue repair, and semisoluble pastes for external repair, shown by skin repair in live mice. Laser repaired intestinal tissue held over seven times more fluid pressure than sutured intestine and also prevented bacterial leakage. Skin incisions in mice closed using LANS' showed indication of increased mechanical strength and faster repair compared to suturing. Laser-activated silk-GNR nanosealants rapidly seal soft-tissue tears and show high promise for tissue approximation and repair in trauma and routine surgery.

Original languageEnglish (US)
JournalAdvanced Functional Materials
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

silk
Silk
Repair
Tissue
Lasers
approximation
lasers
sealing
Nanorods
Gold
nanorods
mice
Skin
Fibroins
gold
intestines
fluid pressure
Polypeptides
polypeptides
Ointments

Keywords

  • gold nanorods
  • sealant
  • tissue repair
  • tissue welding
  • wound healing

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

Cite this

Rapid Soft Tissue Approximation and Repair Using Laser-Activated Silk Nanosealants. / Urie, Russell; Guo, Chengchen; Ghosh, Deepanjan; Thelakkaden, Mitzi; Wong, Valerie; Lee, Jung Keun; Kilbourne, Jacquelyn; Yarger, Jeffery; Rege, Kaushal.

In: Advanced Functional Materials, 01.01.2018.

Research output: Contribution to journalArticle

Urie, Russell ; Guo, Chengchen ; Ghosh, Deepanjan ; Thelakkaden, Mitzi ; Wong, Valerie ; Lee, Jung Keun ; Kilbourne, Jacquelyn ; Yarger, Jeffery ; Rege, Kaushal. / Rapid Soft Tissue Approximation and Repair Using Laser-Activated Silk Nanosealants. In: Advanced Functional Materials. 2018.
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