@article{778a7582d58e4a10a68e2008a03fe5af,
title = "Rapid Soft Tissue Approximation and Repair Using Laser-Activated Silk Nanosealants",
abstract = "Tissue approximation and repair are conventionally performed with sutures and staples, but these means are inherently traumatic. Tissue approximation using laser-responsive nanomaterials can lead to rapid tissue sealing and repair, and is an attractive alternative to existing clinical methods. Here, the use of laser-activated nanosealants (LANS) with gold nanorods (GNRs) embedded in silk fibroin polypeptide matrices is demonstrated. The adaptability of LANS for sealing soft tissues is demonstrated using two different modalities: insoluble thin films for internal, intestinal tissue repair, and semisoluble pastes for external repair, shown by skin repair in live mice. Laser repaired intestinal tissue held over seven times more fluid pressure than sutured intestine and also prevented bacterial leakage. Skin incisions in mice closed using LANS' showed indication of increased mechanical strength and faster repair compared to suturing. Laser-activated silk-GNR nanosealants rapidly seal soft-tissue tears and show high promise for tissue approximation and repair in trauma and routine surgery.",
keywords = "gold nanorods, sealant, tissue repair, tissue welding, wound healing",
author = "Russell Urie and Chengchen Guo and Deepanjan Ghosh and Mitzi Thelakkaden and Valerie Wong and Lee, {Jung Keun} and Jacquelyn Kilbourne and Jeffery Yarger and Kaushal Rege",
note = "Funding Information: The authors thank Dr. Su Lin for access to the Ultrafast Laser Facility at the ASU Biodesign Institute and Mr. Fred Pe{\~n}a for excellent technical assistance. The authors also thank Mr. Yifei Xu and Prof. Lenore Dai, Chemical Engineering, ASU, for help with and access to the rheometer used in the current study. We are grateful to the National Institute for Biomedical Imaging and Bioengineering (NIBIB), NIH (Grant 1R01EB020690 to KR), and the Department of Defense, Air Force Office of Scientific Research (DOD AFOSR, FA9550-17-1-0282, to JLY) for funding this research. We also thank Dr. Michael Jaffe, DVM, previously at Midwestern University, Glendale, AZ, for helpful technical discussions. Funding Information: The authors thank Dr. Su Lin for access to the Ultrafast Laser Facility at the ASU Biodesign Institute and Mr. Fred Pe?a for excellent technical assistance. The authors also thank Mr. Yifei Xu and Prof. Lenore Dai, Chemical Engineering, ASU, for help with and access to the rheometer used in the current study. We are grateful to the National Institute for Biomedical Imaging and Bioengineering (NIBIB), NIH (Grant 1R01EB020690 to KR), and the Department of Defense, Air Force Office of Scientific Research (DOD AFOSR, FA9550-17-1-0282, to JLY) for funding this research. We also thank Dr. Michael Jaffe, DVM, previously at Midwestern University, Glendale, AZ, for helpful technical discussions. Publisher Copyright: {\textcopyright} 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = oct,
day = "17",
doi = "10.1002/adfm.201802874",
language = "English (US)",
volume = "28",
journal = "Advanced Functional Materials",
issn = "1616-301X",
publisher = "Wiley-VCH Verlag",
number = "42",
}