Rapid MR spectroscopic imaging of lactate using compressed sensing

Rohini Vidya Shankar, Shubhangi Agarwal, Sairam Geethanath, Vikram Kodibagkar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Imaging lactate metabolism in vivo may improve cancer targeting and therapeutics due to its key role in the development, maintenance, and metastasis of cancer. The long acquisition times associated with magnetic resonance spectroscopic imaging (MRSI), which is a useful technique for assessing metabolic concentrations, are a deterrent to its routine clinical use. The objective of this study was to combine spectral editing and prospective compressed sensing (CS) acquisitions to enable precise and high-speed imaging of the lactate resonance. A MRSI pulse sequence with two key modifications was developed: (1) spectral editing components for selective detection of lactate, and (2) a variable density sampling mask for pseudo-random under-sampling of the k-space 'on the fly'. The developed sequence was tested on phantoms and in vivo in rodent models of cancer. Datasets corresponding to the 1X (fully-sampled), 2X, 3X, 4X, 5X, and 10X accelerations were acquired. The under-sampled datasets were reconstructed using a custom-built algorithm in MatlabTM, and the fidelity of the CS reconstructions was assessed in terms of the peak amplitudes, SNR, and total acquisition time. The accelerated reconstructions demonstrate a reduction in the scan time by up to 90% in vitro and up to 80% in vivo, with negligible loss of information when compared with the fully-sampled dataset. The proposed unique combination of spectral editing and CS facilitated rapid mapping of the spatial distribution of lactate at high temporal resolution. This technique could potentially be translated to the clinic for the routine assessment of lactate changes in solid tumors.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9417
ISBN (Print)9781628415070
DOIs
StatePublished - 2015
EventMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging - Orlando, United States
Duration: Feb 24 2015Feb 26 2015

Other

OtherMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityOrlando
Period2/24/152/26/15

Fingerprint

Compressed sensing
lactates
Lactic Acid
editing
Imaging techniques
Magnetic resonance
acquisition
cancer
magnetic resonance
Sampling
Neoplasms
sampling
Magnetic Resonance Imaging
rodents
Metabolism
Spatial distribution
Tumors
Masks
metastasis
metabolism

Keywords

  • Cancer
  • Compressed sensing
  • Fast imaging
  • Lactate
  • MR spectroscopy
  • Spectral editing

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Shankar, R. V., Agarwal, S., Geethanath, S., & Kodibagkar, V. (2015). Rapid MR spectroscopic imaging of lactate using compressed sensing. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9417). [94171J] SPIE. https://doi.org/10.1117/12.2084003

Rapid MR spectroscopic imaging of lactate using compressed sensing. / Shankar, Rohini Vidya; Agarwal, Shubhangi; Geethanath, Sairam; Kodibagkar, Vikram.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9417 SPIE, 2015. 94171J.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shankar, RV, Agarwal, S, Geethanath, S & Kodibagkar, V 2015, Rapid MR spectroscopic imaging of lactate using compressed sensing. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9417, 94171J, SPIE, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, Orlando, United States, 2/24/15. https://doi.org/10.1117/12.2084003
Shankar RV, Agarwal S, Geethanath S, Kodibagkar V. Rapid MR spectroscopic imaging of lactate using compressed sensing. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9417. SPIE. 2015. 94171J https://doi.org/10.1117/12.2084003
Shankar, Rohini Vidya ; Agarwal, Shubhangi ; Geethanath, Sairam ; Kodibagkar, Vikram. / Rapid MR spectroscopic imaging of lactate using compressed sensing. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9417 SPIE, 2015.
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