Rapid Kinetics of Size and pH-Dependent Dissolution and Aggregation of Silver Nanoparticles in Simulated Gastric Fluid

Jessica L. Axson, Diana I. Stark, Amy L. Bondy, Sonja S. Capracotta, Andrew Maynard, Martin A. Philbert, Ingrid L. Bergin, Andrew P. Ault

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

As silver nanoparticles (AgNPs) are used in a wide array of commercial products and can enter the human body through oral exposure, it is important to understand the fundamental physical and chemical processes leading to changes in nanoparticle size under the conditions of the gastrointestinal (GI) tract. Rapid AgNP growth was observed using nanoparticle tracking analysis with 30 s resolution over a period of 17 min in simulated gastric fluid (SGF) to explore rapid kinetics as a function of pH (SGF at pH 2, 3.5, 4.5 and 5), size (20 and 110 nm AgNPs), and nanoparticle coating (citrate and PVP). Growth was observed for 20 nm AgNP at each pH, decreasing in rate with increasing pH, with the kinetics shifting from second-order to first-order. The 110 nm AgNP showed growth at ≤3.5 pH, with no growth observed at higher pH. This behavior can be explained by the generation of Ag+ in acidic environments, which precipitates with Cl-, leading to particle growth and facilitating particle aggregation by decreasing their electrostatic repulsion in solution. These results highlight the need to further understand the importance of initial size, physicochemical properties, and kinetics of AgNPs after ingestion to assess potential toxicity.

Original languageEnglish (US)
Pages (from-to)20632-20641
Number of pages10
JournalJournal of Physical Chemistry C
Volume119
Issue number35
DOIs
StatePublished - Jul 28 2015
Externally publishedYes

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Silver
dissolving
Dissolution
Agglomeration
silver
Nanoparticles
nanoparticles
Kinetics
Fluids
fluids
kinetics
ingestion
Citric Acid
human body
Toxicity
citrates
Precipitates
Electrostatics
toxicity
precipitates

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Energy(all)

Cite this

Rapid Kinetics of Size and pH-Dependent Dissolution and Aggregation of Silver Nanoparticles in Simulated Gastric Fluid. / Axson, Jessica L.; Stark, Diana I.; Bondy, Amy L.; Capracotta, Sonja S.; Maynard, Andrew; Philbert, Martin A.; Bergin, Ingrid L.; Ault, Andrew P.

In: Journal of Physical Chemistry C, Vol. 119, No. 35, 28.07.2015, p. 20632-20641.

Research output: Contribution to journalArticle

Axson, Jessica L. ; Stark, Diana I. ; Bondy, Amy L. ; Capracotta, Sonja S. ; Maynard, Andrew ; Philbert, Martin A. ; Bergin, Ingrid L. ; Ault, Andrew P. / Rapid Kinetics of Size and pH-Dependent Dissolution and Aggregation of Silver Nanoparticles in Simulated Gastric Fluid. In: Journal of Physical Chemistry C. 2015 ; Vol. 119, No. 35. pp. 20632-20641.
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