Radio-frequency tissue ablation of VX2 tumor nodules in the rabbit lung.

S. N. Goldberg, G. S. Gazelle, Carolyn Compton, P. R. Mueller, T. C. McLoud

Research output: Contribution to journalArticle

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Abstract

RATIONALE AND OBJECTIVES: The authors investigated whether small pulmonary malignancies could be treated with computed tomography (CT)-guided, percutaneously placed radio-frequency (RF) electrodes. METHODS: Pulmonary tumors were created in 11 New Zealand white rabbits by using CT-guided injection of a VX2 sarcoma cell suspension into the lower portion of the right lung. Tumors were allowed to grow 14-21 days to achieve a diameter of 6-12 mm. Electrodes were placed coaxially into the tumors via insulated 19-gauge Turner needles. Seven tumors were treated with RF for 6 minutes at 90 degrees C. Four tumors served as controls and were not treated. Follow-up CT and histopathologic analysis were performed on days 0-28. Specimens from treated rabbits were examined histopathologically on days 0 and 3 (n = 2 each), and days 1, 5, and 28 (n = 1 each). RESULTS: Immediately following treatment, CT images showed rounded opacities enveloping the tumor. This corresponded histologically to coagulation necrosis of tumor and surrounding alveoli. In all cases, at least 95% of treated tumor nodules were necrotic at histopathologic analysis. Peripheral residual nests of histologically viable tumor were seen in three rabbits (43%). Control rabbits showed growing tumor nodules without necrosis at autopsy (mean survival, 23 days after inoculation). Two RF-treated rabbits (29%) and one control rabbit (25%) had pneumothoraces. CONCLUSION: Percutaneous RF tissue ablation can be used to successfully treat small parenchymal tumor nodules within the lung in an animal model.

Original languageEnglish (US)
Pages (from-to)929-935
Number of pages7
JournalAcademic Radiology
Volume3
Issue number11
StatePublished - Nov 1996
Externally publishedYes

Fingerprint

Radio
Rabbits
Lung
Neoplasms
Tomography
Electrodes
Necrosis
Pneumothorax
Sarcoma
Needles
Autopsy
Suspensions
Animal Models
Injections

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Goldberg, S. N., Gazelle, G. S., Compton, C., Mueller, P. R., & McLoud, T. C. (1996). Radio-frequency tissue ablation of VX2 tumor nodules in the rabbit lung. Academic Radiology, 3(11), 929-935.

Radio-frequency tissue ablation of VX2 tumor nodules in the rabbit lung. / Goldberg, S. N.; Gazelle, G. S.; Compton, Carolyn; Mueller, P. R.; McLoud, T. C.

In: Academic Radiology, Vol. 3, No. 11, 11.1996, p. 929-935.

Research output: Contribution to journalArticle

Goldberg, SN, Gazelle, GS, Compton, C, Mueller, PR & McLoud, TC 1996, 'Radio-frequency tissue ablation of VX2 tumor nodules in the rabbit lung.', Academic Radiology, vol. 3, no. 11, pp. 929-935.
Goldberg SN, Gazelle GS, Compton C, Mueller PR, McLoud TC. Radio-frequency tissue ablation of VX2 tumor nodules in the rabbit lung. Academic Radiology. 1996 Nov;3(11):929-935.
Goldberg, S. N. ; Gazelle, G. S. ; Compton, Carolyn ; Mueller, P. R. ; McLoud, T. C. / Radio-frequency tissue ablation of VX2 tumor nodules in the rabbit lung. In: Academic Radiology. 1996 ; Vol. 3, No. 11. pp. 929-935.
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