TY - GEN
T1 - Racial Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias from the Disease Progression Perspective
AU - Zhao, Haozuo
AU - Chu, Haitao
AU - Zhou, Sicheng
AU - Yu, Fang
AU - Luo, Xianghua
AU - Zhang, Rui
N1 - Funding Information:
ACKNOWLEDGMENT This project was partially supported by the National Institute on Aging 3R01AT009457-04S1 (PI: Zhang).
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Alzheimer's Disease (AD) is a progressive brain disorder that causes declined cognition and affects the patients' daily activities. It is the most common cause of dementia in people older than 65 years in America [1]. About 6.2 million people aged 65 and older were diagnosed with Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) in the U.S. in 2021, and the number is projected to increase to 7.2 million in 2025 and to 13.8 million in 2060 [1]. Health disparities are characterized as preventable gaps in the burden of the disease across different races, socio-economic groups, sex or other subgroups. It is noticed that the prevalence of AD/ADRD is higher among African Americans than Whites, which indicates that racial/ethnic disparity may exist in this disease [2]-[4]. There are no efficient treatments to prevent or reverse the progression of this disease. Unlike AD/ADRD patients, people with mild cognitive impairment (MCI), a prodromal stage of AD/ADRD, can still perform daily activities independently, which makes studies about the progression from MCI to AD/ADRD important. However, limited studies have investigated the potential existence of racial disparities from the disease progression perspective, to the best of our knowledge [5]. This study aimed to fill this gap by evaluating the racial disparities in the progression from MCI to AD/ADRD among African Americans and Whites and examining the promising predictors of disease progression for the overall group and two racial groups separately.
AB - Alzheimer's Disease (AD) is a progressive brain disorder that causes declined cognition and affects the patients' daily activities. It is the most common cause of dementia in people older than 65 years in America [1]. About 6.2 million people aged 65 and older were diagnosed with Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) in the U.S. in 2021, and the number is projected to increase to 7.2 million in 2025 and to 13.8 million in 2060 [1]. Health disparities are characterized as preventable gaps in the burden of the disease across different races, socio-economic groups, sex or other subgroups. It is noticed that the prevalence of AD/ADRD is higher among African Americans than Whites, which indicates that racial/ethnic disparity may exist in this disease [2]-[4]. There are no efficient treatments to prevent or reverse the progression of this disease. Unlike AD/ADRD patients, people with mild cognitive impairment (MCI), a prodromal stage of AD/ADRD, can still perform daily activities independently, which makes studies about the progression from MCI to AD/ADRD important. However, limited studies have investigated the potential existence of racial disparities from the disease progression perspective, to the best of our knowledge [5]. This study aimed to fill this gap by evaluating the racial disparities in the progression from MCI to AD/ADRD among African Americans and Whites and examining the promising predictors of disease progression for the overall group and two racial groups separately.
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U2 - 10.1109/ICHI54592.2022.00107
DO - 10.1109/ICHI54592.2022.00107
M3 - Conference contribution
AN - SCOPUS:85139033730
T3 - Proceedings - 2022 IEEE 10th International Conference on Healthcare Informatics, ICHI 2022
SP - 550
EP - 552
BT - Proceedings - 2022 IEEE 10th International Conference on Healthcare Informatics, ICHI 2022
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 10th IEEE International Conference on Healthcare Informatics, ICHI 2022
Y2 - 11 June 2022 through 14 June 2022
ER -