Quinolinic Acid

J. L. McBride, S. Ramaswamy, J. H. Kordower

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Quinolinic acid (QA) is a metabolite of tryptophan that binds to N-methyl-d-aspartate (NMDA) receptors in the central nervous system. Overstimulation of these receptors leads to excitotoxicity and cell death of neurons harboring these receptors. QA has been widely used in animals to model particular neurodegenerative disorders, especially Huntington's disease.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Pages1-3
Number of pages3
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Keywords

  • Amino acid
  • Animal model
  • Brain
  • Excitotoxicity
  • Glutamate agonist
  • Huntington's disease
  • Kynurenine
  • Neurodegeneration
  • Neurotoxin
  • NMDA receptor
  • Striatum
  • Tryptophan

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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