Quasi-Two-Dimensional Metal Oxide Semiconductors Based Ultrasensitive Potentiometric Biosensors

Huajun Chen; You Seung Rim; Isaac Caleb Wang; Chao Li; Bowen Zhu; Mo Sun; Mark S. Goorsky; Ximin He; Yang Yang

doi:10.1021/acsnano.7b00628

Quasi-Two-Dimensional Metal Oxide Semiconductors Based Ultrasensitive Potentiometric Biosensors

Huajun Chen, You Seung Rim, Isaac Caleb Wang, Chao Li, Bowen Zhu, Mo Sun, Mark S. Goorsky, Ximin He, Yang Yang

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Ultrasensitive field-effect transistor-based biosensors using quasi-two-dimensional metal oxide semiconductors were demonstrated. Quasi-two-dimensional low-dimensional metal oxide semiconductors were highly sensitive to electrical perturbations at the semiconductor-bio interface and showed competitive sensitivity compared with other nanomaterial-based biosensors. Also, the solution process made our platform simple and highly reproducible, which was favorable compared with other nanobioelectronics. A quasi-two-dimensional In₂O₃-based pH sensor showed a small detection limit of 0.0005 pH and detected the glucose concentration at femtomolar levels. Detailed electrical characterization unveiled how the device's parameters affect the biosensor sensitivity, and lowest detectable charge was extrapolated, which was consistent with the experimental data.

Original language	English (US)
Pages (from-to)	4710-4718
Number of pages	9
Journal	ACS nano
Volume	11
Issue number	5
DOIs	https://doi.org/10.1021/acsnano.7b00628
State	Published - May 23 2017
Externally published	Yes

Keywords

field-effect transistor
glucose sensors
oxide semiconductor
pH sensors
quasi-two-dimensional

ASJC Scopus subject areas

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

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10.1021/acsnano.7b00628

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title = "Quasi-Two-Dimensional Metal Oxide Semiconductors Based Ultrasensitive Potentiometric Biosensors",

abstract = "Ultrasensitive field-effect transistor-based biosensors using quasi-two-dimensional metal oxide semiconductors were demonstrated. Quasi-two-dimensional low-dimensional metal oxide semiconductors were highly sensitive to electrical perturbations at the semiconductor-bio interface and showed competitive sensitivity compared with other nanomaterial-based biosensors. Also, the solution process made our platform simple and highly reproducible, which was favorable compared with other nanobioelectronics. A quasi-two-dimensional In2O3-based pH sensor showed a small detection limit of 0.0005 pH and detected the glucose concentration at femtomolar levels. Detailed electrical characterization unveiled how the device's parameters affect the biosensor sensitivity, and lowest detectable charge was extrapolated, which was consistent with the experimental data.",

keywords = "field-effect transistor, glucose sensors, oxide semiconductor, pH sensors, quasi-two-dimensional",

author = "Huajun Chen and Rim, {You Seung} and Wang, {Isaac Caleb} and Chao Li and Bowen Zhu and Mo Sun and Goorsky, {Mark S.} and Ximin He and Yang Yang",

note = "Funding Information: This work was financially supported by grants from the National Science Foundation (Grant No. ECCS-1202231, Program Director Dr. Paul Werbos; ECCS is a program under Engineering Division), National Science Foundation (Grant No. CHE-1230598, Program Manager Linda S. Sapochak), and was supported by the MISP (Ministry of Science, ICT & Future Planning), Korea, under National program for Excellence in Software program (the SW oriented college support grogram) (R7718- 16-1005) supervised by the IITP (Institute for Information & Communications Technology Promotion). Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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doi = "10.1021/acsnano.7b00628",

language = "English (US)",

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AU - Chen, Huajun

AU - Rim, You Seung

AU - Wang, Isaac Caleb

AU - Li, Chao

AU - Zhu, Bowen

AU - Sun, Mo

AU - Goorsky, Mark S.

AU - He, Ximin

AU - Yang, Yang

N1 - Funding Information: This work was financially supported by grants from the National Science Foundation (Grant No. ECCS-1202231, Program Director Dr. Paul Werbos; ECCS is a program under Engineering Division), National Science Foundation (Grant No. CHE-1230598, Program Manager Linda S. Sapochak), and was supported by the MISP (Ministry of Science, ICT & Future Planning), Korea, under National program for Excellence in Software program (the SW oriented college support grogram) (R7718- 16-1005) supervised by the IITP (Institute for Information & Communications Technology Promotion). Publisher Copyright: © 2017 American Chemical Society.

PY - 2017/5/23

Y1 - 2017/5/23

N2 - Ultrasensitive field-effect transistor-based biosensors using quasi-two-dimensional metal oxide semiconductors were demonstrated. Quasi-two-dimensional low-dimensional metal oxide semiconductors were highly sensitive to electrical perturbations at the semiconductor-bio interface and showed competitive sensitivity compared with other nanomaterial-based biosensors. Also, the solution process made our platform simple and highly reproducible, which was favorable compared with other nanobioelectronics. A quasi-two-dimensional In2O3-based pH sensor showed a small detection limit of 0.0005 pH and detected the glucose concentration at femtomolar levels. Detailed electrical characterization unveiled how the device's parameters affect the biosensor sensitivity, and lowest detectable charge was extrapolated, which was consistent with the experimental data.

AB - Ultrasensitive field-effect transistor-based biosensors using quasi-two-dimensional metal oxide semiconductors were demonstrated. Quasi-two-dimensional low-dimensional metal oxide semiconductors were highly sensitive to electrical perturbations at the semiconductor-bio interface and showed competitive sensitivity compared with other nanomaterial-based biosensors. Also, the solution process made our platform simple and highly reproducible, which was favorable compared with other nanobioelectronics. A quasi-two-dimensional In2O3-based pH sensor showed a small detection limit of 0.0005 pH and detected the glucose concentration at femtomolar levels. Detailed electrical characterization unveiled how the device's parameters affect the biosensor sensitivity, and lowest detectable charge was extrapolated, which was consistent with the experimental data.

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KW - oxide semiconductor

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Quasi-Two-Dimensional Metal Oxide Semiconductors Based Ultrasensitive Potentiometric Biosensors

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