Abstract

Over the past 15 years, coil embolization has emerged as an effective treatment option for cerebral aneurysms that is far less invasive than the long-standing convention of surgical clipping. However, aneurysm recurrence after coil embolization is not uncommon: recurrence rates as high as 50% have been reported in the literature. One factor that may contribute to recurrence after coiling is residual flow into the aneurysmal sac. At present, there is limited quantitative knowledge of the relationship between coil packing density and aneurysmal inflow. We present an in vitro fluid dynamic study of basilar tip aneurysm models that elucidates this relationship. At physiologically normal flow rates, we found that a packing density of 28.4% decreased aneurysmal inflow by 31.6% in a wide-neck model, and that a packing density of 36.5% decreased aneurysmal inflow by 49.6% in a narrow-neck model. Results also indicated that coiling reduced aneurysmal inflow more significantly at lower parent vessel flow rates, and that coiling reduced neck-plane velocity magnitudes more significantly for narrow-neck aneurysms. Our study provides novel quantitative information that could ultimately contribute to improved outcomes for patients with cerebral aneurysms by enabling more effective coil embolization.

Original languageEnglish (US)
Pages (from-to)2293-2301
Number of pages9
JournalAnnals of Biomedical Engineering
Volume38
Issue number7
DOIs
StatePublished - Jul 2010

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Steady flow
Fluid dynamics
Flow rate

Keywords

  • Basilar artery
  • Cerebral aneurysm
  • Embolic coils
  • Packing density
  • PIV

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Quantitative effects of coil packing density on cerebral aneurysm fluid dynamics : An in vitro steady flow study. / Haithem Babiker, M.; Fernando Gonzalez, L.; Felipe, Albuquerque; Collins, Daniel; Elvikis, Arius; Frakes, David.

In: Annals of Biomedical Engineering, Vol. 38, No. 7, 07.2010, p. 2293-2301.

Research output: Contribution to journalArticle

Haithem Babiker, M. ; Fernando Gonzalez, L. ; Felipe, Albuquerque ; Collins, Daniel ; Elvikis, Arius ; Frakes, David. / Quantitative effects of coil packing density on cerebral aneurysm fluid dynamics : An in vitro steady flow study. In: Annals of Biomedical Engineering. 2010 ; Vol. 38, No. 7. pp. 2293-2301.
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