Pulsed-field separation of particles in a microfluidic device

J. Regtmeier; R. Eichhorn; T. T. Duong; P. Reimann; D. Anselmetti; A. Ros

doi:10.1140/epje/e2007-00040-y

Pulsed-field separation of particles in a microfluidic device

J. Regtmeier, R. Eichhorn, T. T. Duong, P. Reimann, D. Anselmetti, A. Ros

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We demonstrate the proof-of-principle of a new separation concept for micrometer-sized particles in a structured microfluidic device. Under the action of externally applied, periodic voltage-pulses two different species of like-charged polystyrene beads are observed to simultaneously migrate into opposite directions. Based on a theoretical model of the particle motion in the microdevice that shows good agreement with the experimental measurements, the underlying separation mechanism is identified and explained. Potential biophysical applications, such as cell sorting, are briefly addressed.

Original language	English (US)
Pages (from-to)	335-340
Number of pages	6
Journal	European Physical Journal E
Volume	22
Issue number	4
DOIs	https://doi.org/10.1140/epje/e2007-00040-y
State	Published - Apr 2007
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Biophysics
General Chemistry
General Materials Science
Surfaces and Interfaces

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10.1140/epje/e2007-00040-y

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AU - Eichhorn, R.

AU - Duong, T. T.

AU - Reimann, P.

AU - Anselmetti, D.

AU - Ros, A.

PY - 2007/4

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AB - We demonstrate the proof-of-principle of a new separation concept for micrometer-sized particles in a structured microfluidic device. Under the action of externally applied, periodic voltage-pulses two different species of like-charged polystyrene beads are observed to simultaneously migrate into opposite directions. Based on a theoretical model of the particle motion in the microdevice that shows good agreement with the experimental measurements, the underlying separation mechanism is identified and explained. Potential biophysical applications, such as cell sorting, are briefly addressed.

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Pulsed-field separation of particles in a microfluidic device

Abstract

ASJC Scopus subject areas

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