TY - JOUR
T1 - Pulmonary localization of intravenously injected liposomes.
AU - Fidler, I. J.
AU - Raz, A.
AU - Fogler, W. E.
AU - Poste, G.
PY - 1980
Y1 - 1980
N2 - Clearance from the circulation and tissue distribution of liposomes of differing size, surface charge, and composition injected IV into BALB/c mice have been examined. Large (500-3,400 nm diameter) liposomes are cleared from the circulation more rapidly than small sonicated liposomes (less than 100 nm diameter). Negatively charged liposomes are cleared more rapidly than neutral or positively charged liposomes of the same size. The major site at which liposomes injected IV accumulate, irrespective of their composition, is the liver. Accumulation of liposomes at extrahepatic sites, such as the lung, is influenced by liposome size, charge, and composition. Optimal localization and retention of liposomes in the lung were achieved with large negatively charged multilamellar and reversed evaporation phase liposomes containing phosphatidylserine (PS/PC, 3:7 mol ratio; PS/PC/LL 4.95:4.95:0.1 mol ratio).
AB - Clearance from the circulation and tissue distribution of liposomes of differing size, surface charge, and composition injected IV into BALB/c mice have been examined. Large (500-3,400 nm diameter) liposomes are cleared from the circulation more rapidly than small sonicated liposomes (less than 100 nm diameter). Negatively charged liposomes are cleared more rapidly than neutral or positively charged liposomes of the same size. The major site at which liposomes injected IV accumulate, irrespective of their composition, is the liver. Accumulation of liposomes at extrahepatic sites, such as the lung, is influenced by liposome size, charge, and composition. Optimal localization and retention of liposomes in the lung were achieved with large negatively charged multilamellar and reversed evaporation phase liposomes containing phosphatidylserine (PS/PC, 3:7 mol ratio; PS/PC/LL 4.95:4.95:0.1 mol ratio).
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U2 - 10.1007/978-3-642-81491-4_38
DO - 10.1007/978-3-642-81491-4_38
M3 - Article
C2 - 7232836
AN - SCOPUS:0019281547
SN - 0080-0015
VL - 75
SP - 246
EP - 251
JO - Recent Results in Cancer Research
JF - Recent Results in Cancer Research
ER -