Psychological Factors May Play an Important Role in Pediatric Crohn's Disease Symptoms and Disability

Miranda A L van Tilburg, Robyn Lewis Claar, Joan M. Romano, Shelby Langer, Douglas A. Drossman, William E. Whitehead, Bisher Abdullah, Rona L. Levy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To examine the relative contributions of disease activity and psychological factors to self-reported symptoms and disability in children with Crohn's disease. Study design: Participants (n = 127 children age 8-18 years) completed questionnaires on symptom severity and disability, as well as psychological measures assessing anxiety, depression, pain beliefs and coping. Disease activity was measured by the Pediatric Crohn's Disease Activity Index. Structural equation modeling was used to test the effects of disease activity and psychological factors on symptoms and disability. Results: In the hypothesized model predicting symptoms, psychological factors (β = 0.58; P < .001) were significantly associated with disease symptoms but disease activity was not. The model for disability yielded significant associations for both psychological factors (β = 0.75; P < .001) and disease activity (β = 0.61, P < .05). Conclusion: Crohn's disease symptoms in children and adolescents are not only driven by disease activity. Coping, anxiety, depression, and cognition of illness are important in the patient-reporting of symptom severity and disability. Physicians need to be aware that symptom self-reporting can be driven by psychological factors and may not always be simply an indicator of disease activity. Trial registration: ClinicalTrials.gov: NCT00679003.

Original languageEnglish (US)
JournalJournal of Pediatrics
DOIs
StateAccepted/In press - Oct 6 2016
Externally publishedYes

Fingerprint

Psychology
Crohn Disease
Anxiety
Depression
Pediatric Crohn's disease
Disabled Children
Cognition
Physicians
Pain

Keywords

  • Anxiety
  • Catastrophizing
  • Coping
  • Crohn's disease
  • Depression
  • Disease activity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

van Tilburg, M. A. L., Claar, R. L., Romano, J. M., Langer, S., Drossman, D. A., Whitehead, W. E., ... Levy, R. L. (Accepted/In press). Psychological Factors May Play an Important Role in Pediatric Crohn's Disease Symptoms and Disability. Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2017.01.058

Psychological Factors May Play an Important Role in Pediatric Crohn's Disease Symptoms and Disability. / van Tilburg, Miranda A L; Claar, Robyn Lewis; Romano, Joan M.; Langer, Shelby; Drossman, Douglas A.; Whitehead, William E.; Abdullah, Bisher; Levy, Rona L.

In: Journal of Pediatrics, 06.10.2016.

Research output: Contribution to journalArticle

van Tilburg, Miranda A L ; Claar, Robyn Lewis ; Romano, Joan M. ; Langer, Shelby ; Drossman, Douglas A. ; Whitehead, William E. ; Abdullah, Bisher ; Levy, Rona L. / Psychological Factors May Play an Important Role in Pediatric Crohn's Disease Symptoms and Disability. In: Journal of Pediatrics. 2016.
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