Proximity-enhanced synthesis of DNA-peptide-DNA triblock molecules

Tara MacCulloch, Alexandra Novacek, Nicholas Stephanopoulos

Research output: Contribution to journalArticlepeer-review


We report a proximity-enhanced method to synthesize a peptide flanked by two different oligonucleotide handles. Our method relies on sequential bioorthogonal reactions, and partial hybridization of the second handle to the first. We demonstrate the synthesis of a protease-responsive DNA “latch” and a cyclic bioactive peptide using this method.

Original languageEnglish (US)
Pages (from-to)4044-4047
Number of pages4
JournalChemical Communications
Issue number25
StatePublished - Mar 2 2022

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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