Abstract
Background: Ultra-endurance running is emerging as a popular sport in Western industrialised countries. Gastrointestinal bleeding has been reported to be an adverse effect in these runners. Objective: To see if the oral administration of a proton pump inhibitor would reduce the incidence of gastrointestinal bleeding in an ultramarathon. Methods: In a randomised, double blinded, placebo controlled study, a prophylactic regimen of three days of an oral proton pump inhibitor (pantoprazole 20 mg) was tested in healthy athletes participating in the Spartathlon ultramarathon. The incidence of gastrointestinal bleeding was assessed by a stool guaiac test. Results: Results were obtained for 70 healthy volunteers. The data for 20 of 35 runners in the intervention group and 17 of 35 runners in the placebo group were entered into the final analysis. At the end of the ultramarathon, two subjects in the intervention group and 12 in the placebo group had positive stool guaiac tests (risk difference 0.86; 95% confidence interval 0.45 to 0.96; p = 0.001). Conclusion: A short prophylactic regimen of oral proton pump inhibition can successfully decrease the incidence of gastrointestinal bleeding in participants in an ultramarathon.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 359-362 |
| Number of pages | 4 |
| Journal | British journal of sports medicine |
| Volume | 40 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Proton pump inhibition prevents gastrointestinal bleeding in ultramarathon runners : A randomised, double blinded, placebo controlled study. / Thalmann, M.; Sodeck, G. H.; Kavouras, S.; Matalas, A.; Skenderi, K.; Yannikouris, N.; Domanovits, H.
In: British journal of sports medicine, Vol. 40, No. 4, 01.04.2006, p. 359-362.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proton pump inhibition prevents gastrointestinal bleeding in ultramarathon runners
T2 - A randomised, double blinded, placebo controlled study
AU - Thalmann, M.
AU - Sodeck, G. H.
AU - Kavouras, S.
AU - Matalas, A.
AU - Skenderi, K.
AU - Yannikouris, N.
AU - Domanovits, H.
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Background: Ultra-endurance running is emerging as a popular sport in Western industrialised countries. Gastrointestinal bleeding has been reported to be an adverse effect in these runners. Objective: To see if the oral administration of a proton pump inhibitor would reduce the incidence of gastrointestinal bleeding in an ultramarathon. Methods: In a randomised, double blinded, placebo controlled study, a prophylactic regimen of three days of an oral proton pump inhibitor (pantoprazole 20 mg) was tested in healthy athletes participating in the Spartathlon ultramarathon. The incidence of gastrointestinal bleeding was assessed by a stool guaiac test. Results: Results were obtained for 70 healthy volunteers. The data for 20 of 35 runners in the intervention group and 17 of 35 runners in the placebo group were entered into the final analysis. At the end of the ultramarathon, two subjects in the intervention group and 12 in the placebo group had positive stool guaiac tests (risk difference 0.86; 95% confidence interval 0.45 to 0.96; p = 0.001). Conclusion: A short prophylactic regimen of oral proton pump inhibition can successfully decrease the incidence of gastrointestinal bleeding in participants in an ultramarathon.
AB - Background: Ultra-endurance running is emerging as a popular sport in Western industrialised countries. Gastrointestinal bleeding has been reported to be an adverse effect in these runners. Objective: To see if the oral administration of a proton pump inhibitor would reduce the incidence of gastrointestinal bleeding in an ultramarathon. Methods: In a randomised, double blinded, placebo controlled study, a prophylactic regimen of three days of an oral proton pump inhibitor (pantoprazole 20 mg) was tested in healthy athletes participating in the Spartathlon ultramarathon. The incidence of gastrointestinal bleeding was assessed by a stool guaiac test. Results: Results were obtained for 70 healthy volunteers. The data for 20 of 35 runners in the intervention group and 17 of 35 runners in the placebo group were entered into the final analysis. At the end of the ultramarathon, two subjects in the intervention group and 12 in the placebo group had positive stool guaiac tests (risk difference 0.86; 95% confidence interval 0.45 to 0.96; p = 0.001). Conclusion: A short prophylactic regimen of oral proton pump inhibition can successfully decrease the incidence of gastrointestinal bleeding in participants in an ultramarathon.
UR - http://www.scopus.com/inward/record.url?scp=33645677019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645677019&partnerID=8YFLogxK
U2 - 10.1136/bjsm.2005.024463
DO - 10.1136/bjsm.2005.024463
M3 - Article
C2 - 16556794
AN - SCOPUS:33645677019
VL - 40
SP - 359
EP - 362
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
SN - 0306-3674
IS - 4
ER -