Protein targeting to the yeast vacuole

Joel H. Rothman, Carl Yamashiro, Patricia M. Kane, Tom H. Stevens

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Mutational and gene fusion studies have identified localization signals that target proteins to the yeast lysosome-like vacuole. Genetic analyses have also identified groups of genes (VPS and PEP) whose products are required for recognition of these signals, and sorting and transport of proteins to the vacuole. One of the components involved in protein sorting has been shown to be the vacuolar H+-ATPase, presumably via its role in vacuolar acidification.

Original languageEnglish (US)
Pages (from-to)347-350
Number of pages4
JournalTrends in Biochemical Sciences
Volume14
Issue number8
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Protein Transport
Vacuoles
Sorting
Yeast
Genes
Yeasts
Vacuolar Proton-Translocating ATPases
Fungal Proteins
Acidification
Gene Fusion
Lysosomes
Carrier Proteins
Proteins
Fusion reactions
Peptamen

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Protein targeting to the yeast vacuole. / Rothman, Joel H.; Yamashiro, Carl; Kane, Patricia M.; Stevens, Tom H.

In: Trends in Biochemical Sciences, Vol. 14, No. 8, 01.01.1989, p. 347-350.

Research output: Contribution to journalArticle

Rothman, Joel H. ; Yamashiro, Carl ; Kane, Patricia M. ; Stevens, Tom H. / Protein targeting to the yeast vacuole. In: Trends in Biochemical Sciences. 1989 ; Vol. 14, No. 8. pp. 347-350.
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