Protein targeting to the yeast vacuole

Joel H. Rothman; Carl T. Yamashiro; Patricia M. Kane; Tom H. Stevens

doi:10.1016/0968-0004(89)90170-9

Protein targeting to the yeast vacuole

Joel H. Rothman, Carl T. Yamashiro, Patricia M. Kane, Tom H. Stevens

Arizona State University

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72 Scopus citations

Abstract

Mutational and gene fusion studies have identified localization signals that target proteins to the yeast lysosome-like vacuole. Genetic analyses have also identified groups of genes (VPS and PEP) whose products are required for recognition of these signals, and sorting and transport of proteins to the vacuole. One of the components involved in protein sorting has been shown to be the vacuolar H⁺-ATPase, presumably via its role in vacuolar acidification.

Original language	English (US)
Pages (from-to)	347-350
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	14
Issue number	8
DOIs	https://doi.org/10.1016/0968-0004(89)90170-9
State	Published - Aug 1989

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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title = "Protein targeting to the yeast vacuole",

abstract = "Mutational and gene fusion studies have identified localization signals that target proteins to the yeast lysosome-like vacuole. Genetic analyses have also identified groups of genes (VPS and PEP) whose products are required for recognition of these signals, and sorting and transport of proteins to the vacuole. One of the components involved in protein sorting has been shown to be the vacuolar H+-ATPase, presumably via its role in vacuolar acidification.",

author = "Rothman, {Joel H.} and Yamashiro, {Carl T.} and Kane, {Patricia M.} and Stevens, {Tom H.}",

year = "1989",

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AU - Yamashiro, Carl T.

AU - Kane, Patricia M.

AU - Stevens, Tom H.

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AB - Mutational and gene fusion studies have identified localization signals that target proteins to the yeast lysosome-like vacuole. Genetic analyses have also identified groups of genes (VPS and PEP) whose products are required for recognition of these signals, and sorting and transport of proteins to the vacuole. One of the components involved in protein sorting has been shown to be the vacuolar H+-ATPase, presumably via its role in vacuolar acidification.

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Protein targeting to the yeast vacuole

Abstract

ASJC Scopus subject areas

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