Protein targeting to the yeast vacuole

Joel H. Rothman, Carl T. Yamashiro, Patricia M. Kane, Tom H. Stevens

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Mutational and gene fusion studies have identified localization signals that target proteins to the yeast lysosome-like vacuole. Genetic analyses have also identified groups of genes (VPS and PEP) whose products are required for recognition of these signals, and sorting and transport of proteins to the vacuole. One of the components involved in protein sorting has been shown to be the vacuolar H+-ATPase, presumably via its role in vacuolar acidification.

Original languageEnglish (US)
Pages (from-to)347-350
Number of pages4
JournalTrends in Biochemical Sciences
Volume14
Issue number8
DOIs
StatePublished - Aug 1989

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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    Rothman, J. H., Yamashiro, C. T., Kane, P. M., & Stevens, T. H. (1989). Protein targeting to the yeast vacuole. Trends in Biochemical Sciences, 14(8), 347-350. https://doi.org/10.1016/0968-0004(89)90170-9