Protein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified mice

Michael Foster Olive, Philip M. Newton

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Studies using targeted gene deletion in mice have revealed distinct roles for individual isozymes of the protein kinase C (PKC) family of enzymes in regulating sensitivity to various drugs of abuse. These changes in drug sensitivity are associated with altered patterns of drug self-administration. The purpose of this review is to summarize behavioral studies conducted on mice carrying targeted deletions of genes encoding specific PKC isozymes (namely the β, γ, δ, and ϵ isozymes), and to critically evaluate the possibility of using pharmacological inhibitors of specific PKC isozymes as modulators of the sensitivity to various drugs of abuse, as well as potential aids in the treatment of substance use disorders.

Original languageEnglish (US)
Pages (from-to)493-499
Number of pages7
JournalBehavioural pharmacology
Volume21
Issue number5-6
DOIs
StatePublished - Sep 1 2010

Keywords

  • cannabinoids
  • ethanol
  • isozymes
  • morphine
  • mouse
  • protein kinase C
  • targeted gene deletion

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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