Protein kinase C isozymes and addiction

M. Foster Olive; Robert O. Messing

doi:10.1385/MN:29:2:139

Protein kinase C isozymes and addiction

M. Foster Olive, Robert O. Messing

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Protein kinase C (PKC) has long been recognized an important family of enzymes that regulate numerous aspects of neuronal signal transduction, neurotransmitter synthesis, release and reuptake, receptor and ion channel function, neuronal excitability, development, and gene expression. Much evidence has implicated PKCs in the effects of several drugs of abuse, and in behavioral responses to these drugs. The present review summarizes the effects of both acute and chronic exposure to various drugs of abuse on individual PKC isozymes in the brain. In addition, we summarize recent studies utilizing mice with targeted deletions of the genes for PKCγ and PKCε. These studies suggest that individual PKC isozymes play a role in the development of drug dependence and addiction.

Original language	English (US)
Pages (from-to)	139-153
Number of pages	15
Journal	Molecular Neurobiology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1385/MN:29:2:139
State	Published - Apr 2004
Externally published	Yes

Keywords

Amphetamine
Cocaine
Ethanol
Isozymes
Knockout mouse
Opiates
Protein kinase C

ASJC Scopus subject areas

Neurology
Cellular and Molecular Neuroscience

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10.1385/MN:29:2:139

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title = "Protein kinase C isozymes and addiction",

abstract = "Protein kinase C (PKC) has long been recognized an important family of enzymes that regulate numerous aspects of neuronal signal transduction, neurotransmitter synthesis, release and reuptake, receptor and ion channel function, neuronal excitability, development, and gene expression. Much evidence has implicated PKCs in the effects of several drugs of abuse, and in behavioral responses to these drugs. The present review summarizes the effects of both acute and chronic exposure to various drugs of abuse on individual PKC isozymes in the brain. In addition, we summarize recent studies utilizing mice with targeted deletions of the genes for PKCγ and PKCε. These studies suggest that individual PKC isozymes play a role in the development of drug dependence and addiction.",

keywords = "Amphetamine, Cocaine, Ethanol, Isozymes, Knockout mouse, Opiates, Protein kinase C",

author = "Olive, {M. Foster} and Messing, {Robert O.}",

note = "Funding Information: M. Foster Olive is supported by grants AA13276 and AA013852 from the National Institute on Alcohol Abuse and Alcoholism. R. O. Messing is supported by AA08117 and AA13588 from the National Institute on Alcohol Abuse and Alcoholism. Both authors are also supported by funds provided by the State of California for medical research on alcohol and substance abuse through the University of California at San Francisco.",

year = "2004",

month = apr,

doi = "10.1385/MN:29:2:139",

language = "English (US)",

volume = "29",

pages = "139--153",

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T1 - Protein kinase C isozymes and addiction

AU - Olive, M. Foster

AU - Messing, Robert O.

N1 - Funding Information: M. Foster Olive is supported by grants AA13276 and AA013852 from the National Institute on Alcohol Abuse and Alcoholism. R. O. Messing is supported by AA08117 and AA13588 from the National Institute on Alcohol Abuse and Alcoholism. Both authors are also supported by funds provided by the State of California for medical research on alcohol and substance abuse through the University of California at San Francisco.

PY - 2004/4

Y1 - 2004/4

N2 - Protein kinase C (PKC) has long been recognized an important family of enzymes that regulate numerous aspects of neuronal signal transduction, neurotransmitter synthesis, release and reuptake, receptor and ion channel function, neuronal excitability, development, and gene expression. Much evidence has implicated PKCs in the effects of several drugs of abuse, and in behavioral responses to these drugs. The present review summarizes the effects of both acute and chronic exposure to various drugs of abuse on individual PKC isozymes in the brain. In addition, we summarize recent studies utilizing mice with targeted deletions of the genes for PKCγ and PKCε. These studies suggest that individual PKC isozymes play a role in the development of drug dependence and addiction.

AB - Protein kinase C (PKC) has long been recognized an important family of enzymes that regulate numerous aspects of neuronal signal transduction, neurotransmitter synthesis, release and reuptake, receptor and ion channel function, neuronal excitability, development, and gene expression. Much evidence has implicated PKCs in the effects of several drugs of abuse, and in behavioral responses to these drugs. The present review summarizes the effects of both acute and chronic exposure to various drugs of abuse on individual PKC isozymes in the brain. In addition, we summarize recent studies utilizing mice with targeted deletions of the genes for PKCγ and PKCε. These studies suggest that individual PKC isozymes play a role in the development of drug dependence and addiction.

KW - Amphetamine

KW - Cocaine

KW - Ethanol

KW - Isozymes

KW - Knockout mouse

KW - Opiates

KW - Protein kinase C

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Protein kinase C isozymes and addiction

Abstract

Keywords

ASJC Scopus subject areas

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