Prostaglandin E2 promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor δ

Dingzhi Wang, Haibin Wang, Qiong Shi, Sharada Katkuri, Walter Walhi, Beatrice Desvergne, Sanjoy K. Das, Sudhansu K. Dey, Raymond N. DuBois

Research output: Contribution to journalArticle

266 Scopus citations

Abstract

Cyclooxygenase-derived prostaglandin E2 (PGE2) is the predominant prostanoid found in most colorectal cancers (CRC) and is known to promote colon carcinoma growth and invasion. However, the key downstream signaling pathways necessary for PGE2-induced intestinal carcinogenesis are unclear. Here we report that PGE2 indirectly transactivates PPARδ through PI3K/Akt signaling, which promotes cell survival and intestinal adenoma formation. We also found that PGE2 treatment of Apcmin mice dramatically increased intestinal adenoma burden, which was negated in Apcmin mice lacking PPARδ. We demonstrate that PPARδ is a focal point of crosstalk between the prostaglandin and Wnt signaling pathways which results in a shift from cell death to cell survival, leading to increased tumor growth.

Original languageEnglish (US)
Pages (from-to)285-295
Number of pages11
JournalCancer cell
Volume6
Issue number3
DOIs
StatePublished - Sep 1 2004

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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