Prostaglandin E 2 promotes intestinal tumor growth via DNA methylation

Dianren Xia; Dingzhi Wang; Sun Hee Kim; Hiroshi Katoh; Raymond N. Dubois

doi:10.1038/nm.2608

Prostaglandin E ₂ promotes intestinal tumor growth via DNA methylation

Dianren Xia, Dingzhi Wang, Sun Hee Kim, Hiroshi Katoh, Raymond N. Dubois

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E ₂ (PGE ₂) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE ₂ in the promotion of tumor progression.

Original language	English (US)
Pages (from-to)	224-226
Number of pages	3
Journal	Nature Medicine
Volume	18
Issue number	2
DOIs	https://doi.org/10.1038/nm.2608
State	Published - Feb 2012

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1038/nm.2608

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title = "Prostaglandin E 2 promotes intestinal tumor growth via DNA methylation",

abstract = "Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E 2 (PGE 2) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE 2 in the promotion of tumor progression.",

author = "Dianren Xia and Dingzhi Wang and Kim, {Sun Hee} and Hiroshi Katoh and Dubois, {Raymond N.}",

note = "Funding Information: We thank D. Menter and P. Yang for their suggestions and help in the measurement of PGE2. This work is supported, in part, by the US National Institutes of Health MERIT award grants R37 DK47297, RO1 DK62112, NCI P01 CA77839 and CPRIT RP100960. We also thank the National Colorectal Cancer Research Alliance (NCCRA) for its generous support (R.N.D.) and a cancer prevention fellowship (D.X.) supported by the National Cancer Institute grant R25T CA57730 (principal investigator, S. Chang).",

year = "2012",

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doi = "10.1038/nm.2608",

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AU - Xia, Dianren

AU - Wang, Dingzhi

AU - Kim, Sun Hee

AU - Katoh, Hiroshi

AU - Dubois, Raymond N.

N1 - Funding Information: We thank D. Menter and P. Yang for their suggestions and help in the measurement of PGE2. This work is supported, in part, by the US National Institutes of Health MERIT award grants R37 DK47297, RO1 DK62112, NCI P01 CA77839 and CPRIT RP100960. We also thank the National Colorectal Cancer Research Alliance (NCCRA) for its generous support (R.N.D.) and a cancer prevention fellowship (D.X.) supported by the National Cancer Institute grant R25T CA57730 (principal investigator, S. Chang).

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N2 - Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E 2 (PGE 2) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE 2 in the promotion of tumor progression.

AB - Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E 2 (PGE 2) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE 2 in the promotion of tumor progression.

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Prostaglandin E ₂ promotes intestinal tumor growth via DNA methylation

Abstract

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