Prostaglandin E 2 promotes intestinal tumor growth via DNA methylation

Dianren Xia, Dingzhi Wang, Sun Hee Kim, Hiroshi Katoh, Raymond N. Dubois

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E 2 (PGE 2) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE 2 in the promotion of tumor progression.

Original languageEnglish (US)
Pages (from-to)224-226
Number of pages3
JournalNature Medicine
Volume18
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

Fingerprint

DNA Methylation
Prostaglandins E
Tumors
Growth
Neoplasms
Repair
DNA Repair
Genes
DNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Xia, D., Wang, D., Kim, S. H., Katoh, H., & Dubois, R. N. (2012). Prostaglandin E 2 promotes intestinal tumor growth via DNA methylation. Nature Medicine, 18(2), 224-226. https://doi.org/10.1038/nm.2608

Prostaglandin E 2 promotes intestinal tumor growth via DNA methylation. / Xia, Dianren; Wang, Dingzhi; Kim, Sun Hee; Katoh, Hiroshi; Dubois, Raymond N.

In: Nature Medicine, Vol. 18, No. 2, 02.2012, p. 224-226.

Research output: Contribution to journalArticle

Xia, D, Wang, D, Kim, SH, Katoh, H & Dubois, RN 2012, 'Prostaglandin E 2 promotes intestinal tumor growth via DNA methylation', Nature Medicine, vol. 18, no. 2, pp. 224-226. https://doi.org/10.1038/nm.2608
Xia, Dianren ; Wang, Dingzhi ; Kim, Sun Hee ; Katoh, Hiroshi ; Dubois, Raymond N. / Prostaglandin E 2 promotes intestinal tumor growth via DNA methylation. In: Nature Medicine. 2012 ; Vol. 18, No. 2. pp. 224-226.
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