Prostaglandin E 2 promotes intestinal tumor growth via DNA methylation

Dianren Xia, Dingzhi Wang, Sun Hee Kim, Hiroshi Katoh, Raymond N. Dubois

Research output: Contribution to journalArticlepeer-review

125 Scopus citations

Abstract

Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E 2 (PGE 2) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE 2 in the promotion of tumor progression.

Original languageEnglish (US)
Pages (from-to)224-226
Number of pages3
JournalNature Medicine
Volume18
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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