TY - JOUR
T1 - Prolonged nightly fasting and breast cancer risk
T2 - Findings from NHANES (2009-2010)
AU - Marinac, Catherine R.
AU - Natarajan, Loki
AU - Sears, Dorothy D.
AU - Gallo, Linda C.
AU - Hartman, Sheri J.
AU - Arredondo, Elva
AU - Patterson, Ruth E.
N1 - Funding Information:
C.R. Marinac is a recipient of a NCI-sponsored Ruth L. Kirschstein National Research Service Award (1F31CA183125-01A1). S.J. Hartman is supported by grant 1K07CA181323 from the National Cancer Institute. This work was also supported by the National Cancer Institute Centers for Transdisciplinary ResearchonEnergeticsandCancer(1U54CA155435-01).Finally, philanthropic support was provided by Carol Vassiliadis and her family.
Funding Information:
C.R. Marinac is a recipient of a NCI-sponsored Ruth L. Kirschstein National Research Service Award (1F31CA183125-01A1). S.J. Hartman is supported by grant 1K07CA181323 from the National Cancer Institute. This work was also supported by the National Cancer Institute Centers for Transdisciplinary Researchon Energetics and Cancer (1U54CA155435-01). Finally, philanthropic support was provided by Carol Vassiliadis and her family. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Publisher Copyright:
© 2015 AACR.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Background: A novel line of research has emerged, suggesting that daily feeding-fasting schedules that are synchronized with sleep-wake cycles have metabolic implications that are highly relevant to breast cancer. We examined associations of nighttime fasting duration with biomarkers of breast cancer risk among women in the 2009-2010 U.S. National Health and Nutrition Examination Survey. Methods: Dietary, anthropometric, and HbA1c data were available for 2,212 women, and 2-hour postprandial glucose concentrations were available for 1,066 women. Nighttime fasting duration was calculated using 24-hour food records. Separate linear regression models examined associations of nighttime fasting with HbA1c and 2-hour glucose concentrations. Logistic regression modeled associations of nighttime fasting with elevated HbA1c (HbA1c ≥ 39 mmol/mol or 5.7%) and elevated 2-hour glucose (glucose ≥ 140 mg/dL). All models adjusted for age, education, race/ethnicity, body mass index, total kcal intake, evening kcal intake, and the number of eating episodes per day. Results: Each 3-hour increase in nighttime fasting (roughly 1 SD) was associated with a 4% lower 2-hour glucose measurement [βS, 0.96; 95% confidence interval (CI), 0.93-1.00; P< 0.05], and a nonstatistically significant decrease in HbA1c. Logistic regression models indicate that each 3-hour increase in nighttime fasting duration was associated with roughly a 20% reduced odds of elevated HbA1c (OR, 0.81; 95% CI, 0.68-0.97; P < 0.05) and nonsignificantly reduced odds of elevated 2-hour glucose. Conclusions: A longer nighttime duration was significantly associated with improved glycemic regulation. Impact: Randomized trials are needed to confirm whether prolonged nighttime fasting could improve biomarkers of glucose control, thereby reducing breast cancer risk..
AB - Background: A novel line of research has emerged, suggesting that daily feeding-fasting schedules that are synchronized with sleep-wake cycles have metabolic implications that are highly relevant to breast cancer. We examined associations of nighttime fasting duration with biomarkers of breast cancer risk among women in the 2009-2010 U.S. National Health and Nutrition Examination Survey. Methods: Dietary, anthropometric, and HbA1c data were available for 2,212 women, and 2-hour postprandial glucose concentrations were available for 1,066 women. Nighttime fasting duration was calculated using 24-hour food records. Separate linear regression models examined associations of nighttime fasting with HbA1c and 2-hour glucose concentrations. Logistic regression modeled associations of nighttime fasting with elevated HbA1c (HbA1c ≥ 39 mmol/mol or 5.7%) and elevated 2-hour glucose (glucose ≥ 140 mg/dL). All models adjusted for age, education, race/ethnicity, body mass index, total kcal intake, evening kcal intake, and the number of eating episodes per day. Results: Each 3-hour increase in nighttime fasting (roughly 1 SD) was associated with a 4% lower 2-hour glucose measurement [βS, 0.96; 95% confidence interval (CI), 0.93-1.00; P< 0.05], and a nonstatistically significant decrease in HbA1c. Logistic regression models indicate that each 3-hour increase in nighttime fasting duration was associated with roughly a 20% reduced odds of elevated HbA1c (OR, 0.81; 95% CI, 0.68-0.97; P < 0.05) and nonsignificantly reduced odds of elevated 2-hour glucose. Conclusions: A longer nighttime duration was significantly associated with improved glycemic regulation. Impact: Randomized trials are needed to confirm whether prolonged nighttime fasting could improve biomarkers of glucose control, thereby reducing breast cancer risk..
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U2 - 10.1158/1055-9965.EPI-14-1292
DO - 10.1158/1055-9965.EPI-14-1292
M3 - Article
C2 - 25896523
AN - SCOPUS:84982261475
SN - 1055-9965
VL - 24
SP - 783
EP - 789
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 5
ER -