Progress and prospects in mapping recent selection in the genome

K. R. Thornton, J. D. Jensen, C. Becquet, P. Andolfatto

Research output: Contribution to journalReview article

106 Scopus citations

Abstract

One of the central goals of evolutionary biology is to understand the genetic basis of adaptive evolution. The availability of nearly complete genome sequences from a variety of organisms has facilitated the collection of data on naturally occurring genetic variation on the scale of hundreds of loci to whole genomes. Such data have changed the focus of molecular population genetics from making inferences about adaptive evolution at single loci to identifying which loci, out of hundreds to thousands, have been recent targets of natural selection. A major challenge in this effort is distinguishing the effects of selection from those of the demographic history of populations. Here we review some current progress and remaining challenges in the field.

Original languageEnglish (US)
Pages (from-to)340-348
Number of pages9
JournalHeredity
Volume98
Issue number6
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

Keywords

  • Adaptive evolution
  • Demography
  • Genome scans
  • Hitchhiking
  • Population bottleneck
  • Selective sweeps

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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