Progress and prospects in mapping recent selection in the genome

K. R. Thornton, Jeffrey Jensen, C. Becquet, P. Andolfatto

Research output: Contribution to journalReview article

104 Citations (Scopus)

Abstract

One of the central goals of evolutionary biology is to understand the genetic basis of adaptive evolution. The availability of nearly complete genome sequences from a variety of organisms has facilitated the collection of data on naturally occurring genetic variation on the scale of hundreds of loci to whole genomes. Such data have changed the focus of molecular population genetics from making inferences about adaptive evolution at single loci to identifying which loci, out of hundreds to thousands, have been recent targets of natural selection. A major challenge in this effort is distinguishing the effects of selection from those of the demographic history of populations. Here we review some current progress and remaining challenges in the field.

Original languageEnglish (US)
Pages (from-to)340-348
Number of pages9
JournalHeredity
Volume98
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

Genome
loci
genome
Genetic Selection
Population Genetics
Molecular Biology
History
Demography
molecular genetics
natural selection
population genetics
demographic statistics
Population
Biological Sciences
genetic variation
history
organisms

Keywords

  • Adaptive evolution
  • Demography
  • Genome scans
  • Hitchhiking
  • Population bottleneck
  • Selective sweeps

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Progress and prospects in mapping recent selection in the genome. / Thornton, K. R.; Jensen, Jeffrey; Becquet, C.; Andolfatto, P.

In: Heredity, Vol. 98, No. 6, 06.2007, p. 340-348.

Research output: Contribution to journalReview article

Thornton, KR, Jensen, J, Becquet, C & Andolfatto, P 2007, 'Progress and prospects in mapping recent selection in the genome', Heredity, vol. 98, no. 6, pp. 340-348. https://doi.org/10.1038/sj.hdy.6800967
Thornton, K. R. ; Jensen, Jeffrey ; Becquet, C. ; Andolfatto, P. / Progress and prospects in mapping recent selection in the genome. In: Heredity. 2007 ; Vol. 98, No. 6. pp. 340-348.
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