Programming Morphogenesis through Systems and Synthetic Biology

Jeremy J. Velazquez, Emily Su, Patrick Cahan, Mohammad Ebrahimkhani

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Mammalian tissue development is an intricate, spatiotemporal process of self-organization that emerges from gene regulatory networks of differentiating stem cells. A major goal in stem cell biology is to gain a sufficient understanding of gene regulatory networks and cell–cell interactions to enable the reliable and robust engineering of morphogenesis. Here, we review advances in synthetic biology, single cell genomics, and multiscale modeling, which, when synthesized, provide a framework to achieve the ambitious goal of programming morphogenesis in complex tissues and organoids.

Original languageEnglish (US)
Pages (from-to)415-429
Number of pages15
JournalTrends in Biotechnology
Volume36
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • multicellular systems
  • organoids
  • single cell genomics
  • stem cell self-organization
  • synthetic biology
  • systems biology

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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