TY - JOUR
T1 - Programming Morphogenesis through Systems and Synthetic Biology
AU - Velazquez, Jeremy J.
AU - Su, Emily
AU - Cahan, Patrick
AU - Ebrahimkhani, Mohammad
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/4
Y1 - 2018/4
N2 - Mammalian tissue development is an intricate, spatiotemporal process of self-organization that emerges from gene regulatory networks of differentiating stem cells. A major goal in stem cell biology is to gain a sufficient understanding of gene regulatory networks and cell–cell interactions to enable the reliable and robust engineering of morphogenesis. Here, we review advances in synthetic biology, single cell genomics, and multiscale modeling, which, when synthesized, provide a framework to achieve the ambitious goal of programming morphogenesis in complex tissues and organoids.
AB - Mammalian tissue development is an intricate, spatiotemporal process of self-organization that emerges from gene regulatory networks of differentiating stem cells. A major goal in stem cell biology is to gain a sufficient understanding of gene regulatory networks and cell–cell interactions to enable the reliable and robust engineering of morphogenesis. Here, we review advances in synthetic biology, single cell genomics, and multiscale modeling, which, when synthesized, provide a framework to achieve the ambitious goal of programming morphogenesis in complex tissues and organoids.
KW - multicellular systems
KW - organoids
KW - single cell genomics
KW - stem cell self-organization
KW - synthetic biology
KW - systems biology
UR - http://www.scopus.com/inward/record.url?scp=85041535186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041535186&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2017.11.003
DO - 10.1016/j.tibtech.2017.11.003
M3 - Review article
C2 - 29229492
AN - SCOPUS:85041535186
SN - 0167-7799
VL - 36
SP - 415
EP - 429
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 4
ER -