Production of a monoclonal antibody therapeutic against West Nile virus in plants

Qiang Chen (Inventor)

Research output: Patent

Abstract

In the past decade, West Nile Virus (WNV) in the United States has resulted in more than 29,000 diagnosed cases of infection. These infections can lead to severe neurological disease, long-term morbidity, and in some cases even death. There are no effective and specific antiviral treatments for infection by WNV. There are no currently approved vaccines or therapeutic agents for human use. The impact of WNV infectionparticularly in resource-poor health care systemscalls out for the develop-ment of a cost-effective and safe therapeutic. Researchers at the Biodesign Institute of Arizona State University have produced a therapeutic antibody against West Nile Virus. This antibody can be rapidly produced at high levels in plants. Results to-date have shown that an antibody purity of greater than 95% can be produced in a scalable manner. In a mouse challenge model, the researchers discovered that the antibody acts as both a prophylactic and post-infection therapeutic agent. This antibody therefore may have the potential to protect against infection in mammalian systems. Potential Applications Prophylactic treatment of West Nile Virus infection Post-infection treatment of West Nile Virus infection Benefits and Advantages Scalable: Antibody production in plants can be increased to meet demand. Cost-effective: Economical plant-based production of recombinant antibodies. Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Chen's directory webpage
Original languageEnglish (US)
StatePublished - Dec 14 2009

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West Nile virus
Monoclonal Antibodies
Infection
Antibodies
Virus Diseases
Therapeutics
Antibody Formation
Inventors
Research Personnel
Costs and Cost Analysis
Directories
Antiviral Agents
Vaccines
Morbidity
Delivery of Health Care
Research

Cite this

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title = "Production of a monoclonal antibody therapeutic against West Nile virus in plants",
abstract = "In the past decade, West Nile Virus (WNV) in the United States has resulted in more than 29,000 diagnosed cases of infection. These infections can lead to severe neurological disease, long-term morbidity, and in some cases even death. There are no effective and specific antiviral treatments for infection by WNV. There are no currently approved vaccines or therapeutic agents for human use. The impact of WNV infectionparticularly in resource-poor health care systemscalls out for the develop-ment of a cost-effective and safe therapeutic. Researchers at the Biodesign Institute of Arizona State University have produced a therapeutic antibody against West Nile Virus. This antibody can be rapidly produced at high levels in plants. Results to-date have shown that an antibody purity of greater than 95{\%} can be produced in a scalable manner. In a mouse challenge model, the researchers discovered that the antibody acts as both a prophylactic and post-infection therapeutic agent. This antibody therefore may have the potential to protect against infection in mammalian systems. Potential Applications Prophylactic treatment of West Nile Virus infection Post-infection treatment of West Nile Virus infection Benefits and Advantages Scalable: Antibody production in plants can be increased to meet demand. Cost-effective: Economical plant-based production of recombinant antibodies. Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Chen's directory webpage",
author = "Qiang Chen",
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type = "Patent",

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AU - Chen, Qiang

PY - 2009/12/14

Y1 - 2009/12/14

N2 - In the past decade, West Nile Virus (WNV) in the United States has resulted in more than 29,000 diagnosed cases of infection. These infections can lead to severe neurological disease, long-term morbidity, and in some cases even death. There are no effective and specific antiviral treatments for infection by WNV. There are no currently approved vaccines or therapeutic agents for human use. The impact of WNV infectionparticularly in resource-poor health care systemscalls out for the develop-ment of a cost-effective and safe therapeutic. Researchers at the Biodesign Institute of Arizona State University have produced a therapeutic antibody against West Nile Virus. This antibody can be rapidly produced at high levels in plants. Results to-date have shown that an antibody purity of greater than 95% can be produced in a scalable manner. In a mouse challenge model, the researchers discovered that the antibody acts as both a prophylactic and post-infection therapeutic agent. This antibody therefore may have the potential to protect against infection in mammalian systems. Potential Applications Prophylactic treatment of West Nile Virus infection Post-infection treatment of West Nile Virus infection Benefits and Advantages Scalable: Antibody production in plants can be increased to meet demand. Cost-effective: Economical plant-based production of recombinant antibodies. Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Chen's directory webpage

AB - In the past decade, West Nile Virus (WNV) in the United States has resulted in more than 29,000 diagnosed cases of infection. These infections can lead to severe neurological disease, long-term morbidity, and in some cases even death. There are no effective and specific antiviral treatments for infection by WNV. There are no currently approved vaccines or therapeutic agents for human use. The impact of WNV infectionparticularly in resource-poor health care systemscalls out for the develop-ment of a cost-effective and safe therapeutic. Researchers at the Biodesign Institute of Arizona State University have produced a therapeutic antibody against West Nile Virus. This antibody can be rapidly produced at high levels in plants. Results to-date have shown that an antibody purity of greater than 95% can be produced in a scalable manner. In a mouse challenge model, the researchers discovered that the antibody acts as both a prophylactic and post-infection therapeutic agent. This antibody therefore may have the potential to protect against infection in mammalian systems. Potential Applications Prophylactic treatment of West Nile Virus infection Post-infection treatment of West Nile Virus infection Benefits and Advantages Scalable: Antibody production in plants can be increased to meet demand. Cost-effective: Economical plant-based production of recombinant antibodies. Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Chen's directory webpage

M3 - Patent

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