Production, characterization, and antioxidant activity of fucoxanthin from the marine diatom odontella aurita

Song Xia, Ke Wang, Linglin Wan, Aifen Li, Qiang Hu, Chengwu Zhang

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The production, characterization, and antioxidant capacity of the carotenoid fucoxanthin from the marine diatom Odontella aurita were investigated. The results showed that low light and nitrogen-replete culture medium enhanced the biosynthesis of fucoxanthin. The maximum biomass concentration of 6.36 g L-1 and maximum fucoxanthin concentration of 18.47 mg g-1 were obtained in cultures grown in a bubble column photobioreactor (Ø 3.0 cm inner diameter), resulting in a fucoxanthin volumetric productivity of 7.96 mg L-1 day-1. A slight reduction in biomass production was observed in the scaling up of O. aurita culture in a flat plate photobioreactor, yet yielded a comparable fucoxanthin volumetric productivity. A rapid method was developed for extraction and purification of fucoxanthin. The purified fucoxanthin was identified as all-trans-fucoxanthin, which exhibited strong antioxidant properties, with the effective concentration for 50% scavenging (EC50) of 1,1-dihpenyl-2- picrylhydrazyl (DPPH) radical and 2,2′-Azino-bis(3-ethylbenzthiazoline-6- sulfonic acid (ABTS) radical being 0.14 and 0.03 mg mL-1, respectively. Our results suggested that O. aurita can be a natural source of fucoxanthin for human health and nutrition.

Original languageEnglish (US)
Pages (from-to)2667-2681
Number of pages15
JournalMarine Drugs
Issue number7
StatePublished - Jul 1 2013



  • Antioxidant
  • Fucoxanthin
  • Microalgae
  • Odontella aurita
  • Photobioreactor

ASJC Scopus subject areas

  • Drug Discovery

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