Probing the Action of Chemical Denaturant on an Intrinsically Disordered Protein by Simulation and Experiment

Medicine & Life Sciences

• Intrinsically Disordered Proteins 100%
• Pharmacologic Actions 97%
• Energy Transfer 72%
• Guanidine 35%
• X-Rays 31%
• Urea 25%
• Proteins 25%
• Protein Unfolding 18%
• Hydrogen Bonding 16%
• Water 9%

Engineering & Materials Science

• Proteins 62%
• Denaturation 40%
• Forster resonance energy transfer 40%
• X ray scattering 40%
• Experiments 24%
• Urea 20%
• Chromophores 14%
• Solvation 13%
• Hydrogen bonds 11%
• Free energy 10%
• Atoms 8%
• Trajectories 5%
• Water 4%

Chemical Compounds

• Simulation 43%
• Fluorescence Resonance Energy Transfer 28%
• Small Angle X-Ray Scattering 28%
• Protein 28%
• Denaturation 27%
• Guanidinium Chloride 26%
• Radius of Gyration 22%
• Urea 15%
• Solvation 8%
• Chromophore 8%
• Gibbs Free Energy 7%
• Probe 5%
• Hydrogen 4%
• Solvent 4%