Abstract
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder that most commonly affects middle-aged men. PSC is strongly associated with IBD, and in this setting the risk of colorectal cancer is markedly increased. Cholangiocarcinoma, and its devastating consequences, is another well-recognized complication of PSC. This condition tends to progress to end-stage liver disease, and patients with PSC have reduced survival rates compared with the general population. Despite significant research efforts in this field, the pathogenetic mechanisms of PSC are still incompletely understood, although growing evidence supports the role of genetic and immunologic factors. Effective medical therapy is lacking; liver transplantation is the only curative treatment modality, with excellent outcomes in this patient population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 611-619 |
| Number of pages | 9 |
| Journal | Nature Reviews Gastroenterology and Hepatology |
| Volume | 7 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Gastroenterology
- Hepatology
Cite this
Primary sclerosing cholangitis : Overview and update. / Mendes, Flavia; Lindor, Keith.
In: Nature Reviews Gastroenterology and Hepatology, Vol. 7, No. 11, 11.2010, p. 611-619.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary sclerosing cholangitis
T2 - Overview and update
AU - Mendes, Flavia
AU - Lindor, Keith
PY - 2010/11
Y1 - 2010/11
N2 - Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder that most commonly affects middle-aged men. PSC is strongly associated with IBD, and in this setting the risk of colorectal cancer is markedly increased. Cholangiocarcinoma, and its devastating consequences, is another well-recognized complication of PSC. This condition tends to progress to end-stage liver disease, and patients with PSC have reduced survival rates compared with the general population. Despite significant research efforts in this field, the pathogenetic mechanisms of PSC are still incompletely understood, although growing evidence supports the role of genetic and immunologic factors. Effective medical therapy is lacking; liver transplantation is the only curative treatment modality, with excellent outcomes in this patient population.
AB - Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder that most commonly affects middle-aged men. PSC is strongly associated with IBD, and in this setting the risk of colorectal cancer is markedly increased. Cholangiocarcinoma, and its devastating consequences, is another well-recognized complication of PSC. This condition tends to progress to end-stage liver disease, and patients with PSC have reduced survival rates compared with the general population. Despite significant research efforts in this field, the pathogenetic mechanisms of PSC are still incompletely understood, although growing evidence supports the role of genetic and immunologic factors. Effective medical therapy is lacking; liver transplantation is the only curative treatment modality, with excellent outcomes in this patient population.
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UR - http://www.scopus.com/inward/citedby.url?scp=78049530861&partnerID=8YFLogxK
U2 - 10.1038/nrgastro.2010.155
DO - 10.1038/nrgastro.2010.155
M3 - Article
VL - 7
SP - 611
EP - 619
JO - Nature Reviews Gastroenterology and Hepatology
JF - Nature Reviews Gastroenterology and Hepatology
SN - 1759-5045
IS - 11
ER -