Primary sclerosing cholangitis in children versus adults: lessons for the clinic

Abimbola Adike, Elizabeth J. Carey, Keith Lindor

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Introduction: Primary sclerosing cholangitis (PSC) is a rare cholestatic disorder that presents with multifocal biliary strictures. PSC has a variable course but often leads to progressive liver disease, and most patients will eventually require liver transplantation. PSC has a strong association with inflammatory bowel disease and autoimmune liver disease. Areas covered: The objective of this article is to compare and contrast the clinical features and natural history of PSC in children to adults. We performed a PubMed search of the English literature using keywords ‘primary sclerosing cholangitis’, ‘PSC’, ‘children’, and ‘pediatric.’ Expert commentary: While certain features of PSC are similar in the pediatric and adult population, there are unique features of pediatric PSC. More longitudinal studies are needed to better understand the natural history of pediatric PSC. It is conceivable that treatment for PSC that will alter the course of disease may become available in the future.

Original languageEnglish (US)
Pages (from-to)1025-1032
Number of pages8
JournalExpert Review of Gastroenterology and Hepatology
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 3 2018
Externally publishedYes

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Keywords

  • adults
  • children
  • pediatric
  • Primary sclerosing cholangitis
  • PSC

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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