Primary sclerosing cholangitis: Etiology and immunology

J. S. Crippin, Keith Lindor

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease, the etiology of which remains poorly defined. We have reviewed known abnormalities in both the humoral and cell-mediated immunologic systems and describe the abberant expression of class II HLA antigens on biliary epithelial cells. Further work is needed to unite the known findings into a cogent hypothesis, to explain the association of PSC with ulcerative colitis in some patients, and to guide us in developing effective therapy for this, as yet, untreatable disease.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume4
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Allergy and Immunology
Histocompatibility Antigens Class II
HLA Antigens
Ulcerative Colitis
Liver Diseases
Epithelial Cells
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Primary sclerosing cholangitis : Etiology and immunology. / Crippin, J. S.; Lindor, Keith.

In: European Journal of Gastroenterology and Hepatology, Vol. 4, No. 4, 1992, p. 261-265.

Research output: Contribution to journalArticle

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