Primary sclerosing cholangitis: Etiology and immunology

J. S. Crippin, K. D. Lindor

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease, the etiology of which remains poorly defined. We have reviewed known abnormalities in both the humoral and cell-mediated immunologic systems and describe the abberant expression of class II HLA antigens on biliary epithelial cells. Further work is needed to unite the known findings into a cogent hypothesis, to explain the association of PSC with ulcerative colitis in some patients, and to guide us in developing effective therapy for this, as yet, untreatable disease.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number4
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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