Primary sclerosing cholangitis

C. O. Zein, Keith Lindor

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Primary sclerosing cholangitis is a chronic cholestatic disease characterized by periductal inflammation of intrahepatic and extrahepatic bile ducts with obliterative fibrosis and duct loss. Significant loss of bile ducts leads to interference with bile flow and ultimately results in cirrhosis of the biliary type.1,2 Aside from viral hepatitis and alcoholic liver disease, primary sclerosing cholangitis is one of the most common indications for liver transplantation. Although there is no known beneficial therapy for these patients, research aimed toward better understanding the pathogenetic mechanisms and clinical trials with promising new agents are ongoing.

Original languageEnglish (US)
Pages (from-to)103-112
Number of pages10
JournalSeminars in Gastrointestinal Disease
Volume12
Issue number2
StatePublished - 2001
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Intrahepatic Bile Ducts
Extrahepatic Bile Ducts
Alcoholic Liver Diseases
Biliary Liver Cirrhosis
Bile Ducts
Bile
Liver Transplantation
Hepatitis
Fibrosis
Chronic Disease
Clinical Trials
Inflammation
Research
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Primary sclerosing cholangitis. / Zein, C. O.; Lindor, Keith.

In: Seminars in Gastrointestinal Disease, Vol. 12, No. 2, 2001, p. 103-112.

Research output: Contribution to journalArticle

Zein, C. O. ; Lindor, Keith. / Primary sclerosing cholangitis. In: Seminars in Gastrointestinal Disease. 2001 ; Vol. 12, No. 2. pp. 103-112.
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