Primary biliary cirrhosis: An infectious disease caused by Chlamydia pneumoniae?

Ahmad S. Abdulkarim, Lydia M. Petrovic, Woong R. Kim, Paul Angulo, Ricardo V. Lloyd, Keith Lindor

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Background/Aims: The etiology and pathogenesis of primary biliary cirrhosis (PBC) remain elusive. Both an infectious etiology and molecular mimicry have been implicated. The aim is to study the prevalence of Chlamydial antigens and RNA in the liver tissue of patients with PBC. Methods: We compared the prevalence of Chlamydial antigen and RNA in 25 explants with PBC who underwent orthotopic liver transplantation with 105 explanted livers from other chronic liver disease. We also studied 14 liver biopsies from patients with early stages of PBC. Donor livers were also studied. Results: In all 39 patients with PBC, Chlamydia pneumoniae antigens were present but not Chlamydia trachomatis, and only 9/105 (8.5%) of patients in the other categories were positive (P<0.01) for C. pneumoniae. Eight explanted PBC livers were tested for C. pneumoniae 16S RNA by in situ hybridization and were positive. Conclusions: The presence of C. pneumoniae antigen and RNA in liver tissue of patients with PBC suggests that C. pneumoniae antigen may trigger an immune response based on molecular mimicry.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalJournal of Hepatology
Volume40
Issue number3
DOIs
Publication statusPublished - Mar 2004
Externally publishedYes

    Fingerprint

Keywords

  • Chlamydia pneumoniae
  • Pathogenesis
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Gastroenterology

Cite this