Primary biliary cirrhosis.

J. M. Laurin, Keith Lindor

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Primary biliary cirrhosis is a chronic, usually progressive, cholestatic liver disease of presumed autoimmune etiology that affects predominantly young and middle-aged women. It is nearly always associated with an antibody directed against a component of the pyruvate dehydrogenase complex located on the inner wall of the mitochondria. The disease is associated with a number of other associated autoimmune disorders. No totally effective medical treatment has been established for the disease, although urosdeoxycholic acid appears promising. Complications of cholestasis such as fat malabsorption and fat-soluble vitamin deficiency should be excluded or corrected when found. Individual patient prognosis varies. Several models for estimating individual patient survival are available. Liver transplantation is recognized as a procedure to extend and improve the quality of life for patients with advanced disease.

Original languageEnglish (US)
Pages (from-to)331-350
Number of pages20
JournalDigestive Diseases
Volume12
Issue number6
StatePublished - Nov 1994
Externally publishedYes

Fingerprint

Biliary Liver Cirrhosis
Fats
Pyruvate Dehydrogenase Complex
Avitaminosis
Cholestasis
Liver Transplantation
Liver Diseases
Mitochondria
Quality of Life
Acids
Survival
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Laurin, J. M., & Lindor, K. (1994). Primary biliary cirrhosis. Digestive Diseases, 12(6), 331-350.

Primary biliary cirrhosis. / Laurin, J. M.; Lindor, Keith.

In: Digestive Diseases, Vol. 12, No. 6, 11.1994, p. 331-350.

Research output: Contribution to journalArticle

Laurin, JM & Lindor, K 1994, 'Primary biliary cirrhosis.', Digestive Diseases, vol. 12, no. 6, pp. 331-350.
Laurin JM, Lindor K. Primary biliary cirrhosis. Digestive Diseases. 1994 Nov;12(6):331-350.
Laurin, J. M. ; Lindor, Keith. / Primary biliary cirrhosis. In: Digestive Diseases. 1994 ; Vol. 12, No. 6. pp. 331-350.
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