Prevalence of cytomegalovirus in the gastrointestinal tract of renal transplant recipients with persistent abdominal pain

B. Kaplan, H. U. Meier-Kriesche, M. G. Jacobs, G. Friedman, L. Bonomini, P. Defranco, E. Gelfand, S. Mulgaonkar

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

· Abdominal pain occurs frequently in renal transplant recipients receiving mycophenolate mofetll (MMF) therapy. The cause of this abdominal pain has not been fully elucidated, but may involve local irritation, as well as inhibition of rapidly dividing cells of the gastrointestinal (GI) tract. This milieu of inflammation and added immunosuppression is conducive to activation of cytomegalovirus (CMV). We therefore sought to find the prevalence of active CMV in patients presenting with abdominal pain on maintenance MMF therapy. All patients receiving a renal transplant at our center from March 1, 1997, to September 1, 1997, were studied. Any patient presenting with midepigastric pain for greater than 3 days underwent esophagogastroduodenoscopy (EGD) with biopsy. CMV was diagnosed by the presence of inclusion bodies and immunohistochemical studies. Ten patients presented with persistent midepigastric pain; nine of these patients had evidence of GI CMV. Patients who were CMV negative and received an allograft from CMV-positive donors and those with leukopenia were at significantly increased risk for the development of abdominal pain in our study population, the majority of patients on maintenance MMF therapy who presented with persistent midepigastric pain had evidence of active CMV infection in the upper gastrointestinal tract.

Original languageEnglish (US)
Pages (from-to)65-68
Number of pages4
JournalAmerican Journal of Kidney Diseases
Volume34
Issue number1
StatePublished - 1999
Externally publishedYes

Fingerprint

Cytomegalovirus
Abdominal Pain
Gastrointestinal Tract
Kidney
Pain
Maintenance
Digestive System Endoscopy
Upper Gastrointestinal Tract
Inclusion Bodies
Leukopenia
Cytomegalovirus Infections
Transplant Recipients
Immunosuppression
Allografts
Therapeutics
Tissue Donors
Inflammation
Transplants
Biopsy
Population

Keywords

  • CMV
  • GI
  • MMF
  • Renal transplant

ASJC Scopus subject areas

  • Nephrology

Cite this

Kaplan, B., Meier-Kriesche, H. U., Jacobs, M. G., Friedman, G., Bonomini, L., Defranco, P., ... Mulgaonkar, S. (1999). Prevalence of cytomegalovirus in the gastrointestinal tract of renal transplant recipients with persistent abdominal pain. American Journal of Kidney Diseases, 34(1), 65-68.

Prevalence of cytomegalovirus in the gastrointestinal tract of renal transplant recipients with persistent abdominal pain. / Kaplan, B.; Meier-Kriesche, H. U.; Jacobs, M. G.; Friedman, G.; Bonomini, L.; Defranco, P.; Gelfand, E.; Mulgaonkar, S.

In: American Journal of Kidney Diseases, Vol. 34, No. 1, 1999, p. 65-68.

Research output: Contribution to journalArticle

Kaplan, B, Meier-Kriesche, HU, Jacobs, MG, Friedman, G, Bonomini, L, Defranco, P, Gelfand, E & Mulgaonkar, S 1999, 'Prevalence of cytomegalovirus in the gastrointestinal tract of renal transplant recipients with persistent abdominal pain', American Journal of Kidney Diseases, vol. 34, no. 1, pp. 65-68.
Kaplan, B. ; Meier-Kriesche, H. U. ; Jacobs, M. G. ; Friedman, G. ; Bonomini, L. ; Defranco, P. ; Gelfand, E. ; Mulgaonkar, S. / Prevalence of cytomegalovirus in the gastrointestinal tract of renal transplant recipients with persistent abdominal pain. In: American Journal of Kidney Diseases. 1999 ; Vol. 34, No. 1. pp. 65-68.
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