Prevalence of cytomegalovirus in the gastrointestinal tract of renal transplant recipients with persistent abdominal pain

B. Kaplan, H. U. Meier-Kriesche, M. G. Jacobs, G. Friedman, L. Bonomini, P. Defranco, E. Gelfand, S. Mulgaonkar

    Research output: Contribution to journalArticlepeer-review

    44 Scopus citations

    Abstract

    · Abdominal pain occurs frequently in renal transplant recipients receiving mycophenolate mofetll (MMF) therapy. The cause of this abdominal pain has not been fully elucidated, but may involve local irritation, as well as inhibition of rapidly dividing cells of the gastrointestinal (GI) tract. This milieu of inflammation and added immunosuppression is conducive to activation of cytomegalovirus (CMV). We therefore sought to find the prevalence of active CMV in patients presenting with abdominal pain on maintenance MMF therapy. All patients receiving a renal transplant at our center from March 1, 1997, to September 1, 1997, were studied. Any patient presenting with midepigastric pain for greater than 3 days underwent esophagogastroduodenoscopy (EGD) with biopsy. CMV was diagnosed by the presence of inclusion bodies and immunohistochemical studies. Ten patients presented with persistent midepigastric pain; nine of these patients had evidence of GI CMV. Patients who were CMV negative and received an allograft from CMV-positive donors and those with leukopenia were at significantly increased risk for the development of abdominal pain in our study population, the majority of patients on maintenance MMF therapy who presented with persistent midepigastric pain had evidence of active CMV infection in the upper gastrointestinal tract.

    Original languageEnglish (US)
    Pages (from-to)65-68
    Number of pages4
    JournalAmerican Journal of Kidney Diseases
    Volume34
    Issue number1
    DOIs
    StatePublished - 1999

    Keywords

    • CMV
    • GI
    • MMF
    • Renal transplant

    ASJC Scopus subject areas

    • Nephrology

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