TY - JOUR
T1 - Preliminary report
T2 - Hepatic fat and inflammation in type 2 diabetes mellitus
AU - Saremi, Aramesh
AU - Allison, Matthew
AU - Ditomasso, Dominic
AU - Ge, Ling
AU - Anderson, Robert
AU - Moritz, Tom E.
AU - Duckworth, William
AU - Abraira, Carlos
AU - Reaven, Peter D.
N1 - Funding Information:
We would like to thank the VADT study participants, study staff, and the investigators at the Phoenix, San Diego, Long Beach, Hines, Pittsburgh, Tucson, and Miami Veteran Affairs Medical Centers for the participation in this study. We would also like to acknowledge the contributions of the Hines VA Cooperative Studies Program Coordinating Center, the Tufts Lipid Metabolism Laboratory, and the Harbor UCLA EBCT Reading Center. This work was supported by the Office of Research and Development, Medical Research Service and Cooperative Studies Program, Department of Veteran Affairs, and by NIH Grants No. RO1067690 (PDR), P01 HL076491. P01 HL77107, HL70621, Kronos Research Institute, and a clinical research award from the American Diabetes Association (PDR). The authors attest that no conflict of interest or duality exists related to this work.
PY - 2010/3
Y1 - 2010/3
N2 - Although the association between inflammation and hepatic fat is fairly established, it remains unclear whether this association is independent of general measures of obesity and standard cardiovascular risk factors. Therefore, the aim of this study was to investigate the contribution of hepatic steatosis as an independent predictor of chronic inflammation in 281 subjects with type 2 diabetes mellitus. Reduced hepatic steatosis significantly (P < .01) correlated with C-reactive protein (r = -0.16) and adiponectin (r = 0.23). The association of hepatic steatosis with both C-reactive protein and adiponectin remained significant after adjustment for age, ethnicity, body mass index (or waist circumference), triglycerides, high-density lipoprotein, and total cholesterol. These data support the concept that accumulation of hepatic fat is related to enhanced inflammation in type 2 diabetes mellitus independent of general measures of obesity and standard cardiovascular risk factors.
AB - Although the association between inflammation and hepatic fat is fairly established, it remains unclear whether this association is independent of general measures of obesity and standard cardiovascular risk factors. Therefore, the aim of this study was to investigate the contribution of hepatic steatosis as an independent predictor of chronic inflammation in 281 subjects with type 2 diabetes mellitus. Reduced hepatic steatosis significantly (P < .01) correlated with C-reactive protein (r = -0.16) and adiponectin (r = 0.23). The association of hepatic steatosis with both C-reactive protein and adiponectin remained significant after adjustment for age, ethnicity, body mass index (or waist circumference), triglycerides, high-density lipoprotein, and total cholesterol. These data support the concept that accumulation of hepatic fat is related to enhanced inflammation in type 2 diabetes mellitus independent of general measures of obesity and standard cardiovascular risk factors.
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U2 - 10.1016/j.metabol.2009.07.041
DO - 10.1016/j.metabol.2009.07.041
M3 - Article
C2 - 19850309
AN - SCOPUS:76249089657
SN - 0026-0495
VL - 59
SP - 430
EP - 432
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 3
ER -