TY - JOUR
T1 - Pregnancy-induced hypertension
T2 - Development of a model in the pregnant sheep
AU - Thatcher, Craig D.
AU - Keith, James C.
N1 - Funding Information:
From the Division of Veterinary Biology and Clinical Studies, Vir-ginia-M aryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University. This work was supported by Virginia-Maryland Regional College of Veterinary Medicine's New Investigator Grant Program, Virginia Polytechnic Institute and State University. Presented at the Sixty-fifth Conference of Research Workers in Animal Disease, Chicago, Illinois, November 12-13, 1984. Received for publication August 29, 1985; revised January 24, 1986; accepted March 7, 1986. Reprint requests: Craig D. Thatcher, D. V.M., Ph.D., Division of Veterinary Biology and Clinical Studies, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1986/7
Y1 - 1986/7
N2 - Selected hemodynamic, renal, and biochemical parameters were assessed in chronically instrumented third-trimester pregnant ewes and in the same ewes after induction of pregnancy toxemia. Ewes with induced pregnancy toxemia developed hypertension, proteinuria, ketonuria, decreased glomerular filtration rate, decreased cardiac output, and decreased left uterine artery blood flow. Histological and transmission electron microscopy revealed the development of renal morphologic changes consistent with those observed in human pregnancy-induced hypertension. These studies have elucidated that pregnancy-induced hypertension can be produced experimentally in the pregnant ewe. Furthermore, the pathophysiologic features of ovine pregnancy toxemia are similar to those of human preeclampsia, and therefore the sheep provides a suitable animal model to study the human condition, which still remains a major complication of pregnancy, jeopardizing both mother and fetus.
AB - Selected hemodynamic, renal, and biochemical parameters were assessed in chronically instrumented third-trimester pregnant ewes and in the same ewes after induction of pregnancy toxemia. Ewes with induced pregnancy toxemia developed hypertension, proteinuria, ketonuria, decreased glomerular filtration rate, decreased cardiac output, and decreased left uterine artery blood flow. Histological and transmission electron microscopy revealed the development of renal morphologic changes consistent with those observed in human pregnancy-induced hypertension. These studies have elucidated that pregnancy-induced hypertension can be produced experimentally in the pregnant ewe. Furthermore, the pathophysiologic features of ovine pregnancy toxemia are similar to those of human preeclampsia, and therefore the sheep provides a suitable animal model to study the human condition, which still remains a major complication of pregnancy, jeopardizing both mother and fetus.
KW - Pregnancy-induced hypertension
KW - preeclampsia
KW - renal
KW - sheep
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U2 - 10.1016/0002-9378(86)90111-0
DO - 10.1016/0002-9378(86)90111-0
M3 - Article
C2 - 3728588
AN - SCOPUS:0022600761
SN - 0002-9378
VL - 155
SP - 201
EP - 207
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 1
ER -