Prediction of Intra- and Interspecies Protein-Protein Interactions Facilitating Systems Biology Studies

Sylvia Schleker, Seshan Ananthasubramanian, Judith Klein-Seetharaman, Madhavi K. Ganapathiraju

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Protein-protein interactions are critical to virtually all processes in living cells and contribute to many disease mechanisms. The complexity of the many interactions in cells requires a system-wide view, referred to as interactomes. Here, we review current experimental and computational identification approaches to obtain interactomes related to human. Because humans are subject to attack by pathogens, and the pathogens are fully dependent on exploiting the human host for their purposes, interactions between human and pathogen proteins are highly disease relevant. Therefore, in addition to intraspeciesinteractome identification for human, we here also review bacterial interactomes, as well as human-bacteria and human-virus interspecies interactome studies.

Original languageEnglish (US)
Title of host publicationProtein-Protein Interactions in Drug Discovery
PublisherWiley-VCH Verlag
Pages21-53
Number of pages33
Volume56
ISBN (Electronic)9783527648207
ISBN (Print)9783527331079
DOIs
StatePublished - Feb 26 2013
Externally publishedYes

Keywords

  • Computational prediction
  • Disease
  • Drug discovery
  • Interactome
  • Protein-protein interaction
  • Systems biology

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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