Abstract
Protein-protein interactions are critical to virtually all processes in living cells and contribute to many disease mechanisms. The complexity of the many interactions in cells requires a system-wide view, referred to as interactomes. Here, we review current experimental and computational identification approaches to obtain interactomes related to human. Because humans are subject to attack by pathogens, and the pathogens are fully dependent on exploiting the human host for their purposes, interactions between human and pathogen proteins are highly disease relevant. Therefore, in addition to intraspeciesinteractome identification for human, we here also review bacterial interactomes, as well as human-bacteria and human-virus interspecies interactome studies.
Original language | English (US) |
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Title of host publication | Protein-Protein Interactions in Drug Discovery |
Publisher | Wiley-VCH Verlag |
Pages | 21-53 |
Number of pages | 33 |
Volume | 56 |
ISBN (Electronic) | 9783527648207 |
ISBN (Print) | 9783527331079 |
DOIs | |
State | Published - Feb 26 2013 |
Externally published | Yes |
Keywords
- Computational prediction
- Disease
- Drug discovery
- Interactome
- Protein-protein interaction
- Systems biology
ASJC Scopus subject areas
- General Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)