Predicting substance use in emerging adulthood

A genetically informed study of developmental transactions between impulsivity and family conflict

Kit Elam, Frances L. Wang, Kaitlin Bountress, Laurie Chassin, Danielle Pandika, Kathryn Lemery

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Deviance proneness models propose a multilevel interplay in which transactions among genetic, individual, and family risk factors place children at increased risk for substance use. We examined bidirectional transactions between impulsivity and family conflict from middle childhood to adolescence and their contributions to substance use in adolescence and emerging adulthood (n = 380). Moreover, we examined children's, mothers', and fathers' polygenic risk scores for behavioral undercontrol, and mothers' and fathers' interparental conflict and substance disorder diagnoses as predictors of these transactions. The results support a developmental cascade model in which children's polygenic risk scores predicted greater impulsivity in middle childhood. Impulsivity in middle childhood predicted greater family conflict in late childhood, which in turn predicted greater impulsivity in late adolescence. Adolescent impulsivity subsequently predicted greater substance use in emerging adulthood. Results are discussed with respect to evocative genotype-environment correlations within developmental cascades and applications to prevention efforts.

Original languageEnglish (US)
Pages (from-to)673-688
Number of pages16
JournalDevelopment and Psychopathology
Volume28
Issue number3
DOIs
StatePublished - Aug 1 2016

Fingerprint

Family Conflict
Impulsive Behavior
Fathers
Mothers
Genotype

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Predicting substance use in emerging adulthood : A genetically informed study of developmental transactions between impulsivity and family conflict. / Elam, Kit; Wang, Frances L.; Bountress, Kaitlin; Chassin, Laurie; Pandika, Danielle; Lemery, Kathryn.

In: Development and Psychopathology, Vol. 28, No. 3, 01.08.2016, p. 673-688.

Research output: Contribution to journalArticle

@article{c3aa1474437f4cff94bc2b2f1951b174,
title = "Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict",
abstract = "Deviance proneness models propose a multilevel interplay in which transactions among genetic, individual, and family risk factors place children at increased risk for substance use. We examined bidirectional transactions between impulsivity and family conflict from middle childhood to adolescence and their contributions to substance use in adolescence and emerging adulthood (n = 380). Moreover, we examined children's, mothers', and fathers' polygenic risk scores for behavioral undercontrol, and mothers' and fathers' interparental conflict and substance disorder diagnoses as predictors of these transactions. The results support a developmental cascade model in which children's polygenic risk scores predicted greater impulsivity in middle childhood. Impulsivity in middle childhood predicted greater family conflict in late childhood, which in turn predicted greater impulsivity in late adolescence. Adolescent impulsivity subsequently predicted greater substance use in emerging adulthood. Results are discussed with respect to evocative genotype-environment correlations within developmental cascades and applications to prevention efforts.",
author = "Kit Elam and Wang, {Frances L.} and Kaitlin Bountress and Laurie Chassin and Danielle Pandika and Kathryn Lemery",
year = "2016",
month = "8",
day = "1",
doi = "10.1017/S0954579416000249",
language = "English (US)",
volume = "28",
pages = "673--688",
journal = "Development and Psychopathology",
issn = "0954-5794",
publisher = "Cambridge University Press",
number = "3",

}

TY - JOUR

T1 - Predicting substance use in emerging adulthood

T2 - A genetically informed study of developmental transactions between impulsivity and family conflict

AU - Elam, Kit

AU - Wang, Frances L.

AU - Bountress, Kaitlin

AU - Chassin, Laurie

AU - Pandika, Danielle

AU - Lemery, Kathryn

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Deviance proneness models propose a multilevel interplay in which transactions among genetic, individual, and family risk factors place children at increased risk for substance use. We examined bidirectional transactions between impulsivity and family conflict from middle childhood to adolescence and their contributions to substance use in adolescence and emerging adulthood (n = 380). Moreover, we examined children's, mothers', and fathers' polygenic risk scores for behavioral undercontrol, and mothers' and fathers' interparental conflict and substance disorder diagnoses as predictors of these transactions. The results support a developmental cascade model in which children's polygenic risk scores predicted greater impulsivity in middle childhood. Impulsivity in middle childhood predicted greater family conflict in late childhood, which in turn predicted greater impulsivity in late adolescence. Adolescent impulsivity subsequently predicted greater substance use in emerging adulthood. Results are discussed with respect to evocative genotype-environment correlations within developmental cascades and applications to prevention efforts.

AB - Deviance proneness models propose a multilevel interplay in which transactions among genetic, individual, and family risk factors place children at increased risk for substance use. We examined bidirectional transactions between impulsivity and family conflict from middle childhood to adolescence and their contributions to substance use in adolescence and emerging adulthood (n = 380). Moreover, we examined children's, mothers', and fathers' polygenic risk scores for behavioral undercontrol, and mothers' and fathers' interparental conflict and substance disorder diagnoses as predictors of these transactions. The results support a developmental cascade model in which children's polygenic risk scores predicted greater impulsivity in middle childhood. Impulsivity in middle childhood predicted greater family conflict in late childhood, which in turn predicted greater impulsivity in late adolescence. Adolescent impulsivity subsequently predicted greater substance use in emerging adulthood. Results are discussed with respect to evocative genotype-environment correlations within developmental cascades and applications to prevention efforts.

UR - http://www.scopus.com/inward/record.url?scp=84978785992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978785992&partnerID=8YFLogxK

U2 - 10.1017/S0954579416000249

DO - 10.1017/S0954579416000249

M3 - Article

VL - 28

SP - 673

EP - 688

JO - Development and Psychopathology

JF - Development and Psychopathology

SN - 0954-5794

IS - 3

ER -