Prebiotic RNA network formation: A taxonomy of molecular cooperation

Cole Mathis, Sanjay N. Ramprasad, Sara Walker, Niles Lehman

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Cooperation is essential for evolution of biological complexity. Recent work has shown game theoretic arguments, commonly used to model biological cooperation, can also illuminate the dynamics of chemical systems. Here we investigate the types of cooperation possible in a real RNA system based on the Azoarcus ribozyme, by constructing a taxonomy of possible cooperative groups. We construct a computational model of this system to investigate the features of the real system promoting cooperation. We find triplet interactions among genotypes are intrinsically biased towards cooperation due to the particular distribution of catalytic rate constants measured empirically in the real system. For other distributions cooperation is less favored. We discuss implications for understanding cooperation as a driver of complexification in the origin of life.

Original languageEnglish (US)
Article number38
JournalLife
Volume7
Issue number4
DOIs
StatePublished - Dec 2017

Keywords

  • Cooperation
  • Origin of life
  • Prebiotic chemistry
  • RNA
  • Ribozymes
  • Taxonomy

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

Fingerprint

Dive into the research topics of 'Prebiotic RNA network formation: A taxonomy of molecular cooperation'. Together they form a unique fingerprint.

Cite this