Preanalytics and precision pathology: Pathology practices to ensure molecular integrity of cancer patient biospecimens for precision medicine

Carolyn C. Compton, James A. Robb, Matthew W. Anderson, Anna B. Berry, George G. Birdsong, Kenneth J. Bloom, Philip A. Branton, Jessica W. Crothers, Allison M. Cushman-Vokoun, David G. Hicks, Joseph D. Khoury, Jordan Laser, Carrie B. Marshall, Michael J. Misialek, Kristen E. Natale, Jan Anthony Nowak, Damon Olson, John D. Pfeifer, Andrew Schade, Gail H. VanceEric E. Walk, Sophia Louise Yohe

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Biospecimens acquired during routine medical practice are the primary sources of molecular information about patients and their diseases that underlies precision medicine and translational research. In cancer care, molecular analysis of biospecimens is especially common because it often determines treatment choices and may be used to monitor therapy in real time. However, patient specimens are collected, handled, and processed according to routine clinical procedures during which they are subjected to factors that may alter their molecular quality and composition. Such artefactual alteration may skew data from molecular analyses, render analysis data uninterpretable, or even preclude analysis altogether if the integrity of a specimen is severely compromised. As a result, patient care and safety may be affected, and medical research dependent on patient samples may be compromised. Despite these issues, there is currently no requirement to control or record preanalytical variables in clinical practice with the single exception of breast cancer tissue handled according to the guideline jointly developed by the American Society of Clinical Oncology and College of American Pathologists (CAP) and enforced through the CAP Laboratory Accreditation Program. Recognizing the importance of molecular data derived from patient specimens, the CAP Personalized Healthcare Committee established the Preanalytics for Precision Medicine Project Team to develop a basic set of evidence-based recommendations for key preanalytics for tissue and blood specimens. If used for biospecimens from patients, these preanalytical recommendations would ensure the fitness of those specimens for molecular analysis and help to assure the quality and reliability of the analysis data.

Original languageEnglish (US)
Pages (from-to)1346-1363
Number of pages18
JournalArchives of Pathology and Laboratory Medicine
Volume143
Issue number11
DOIs
StatePublished - Jan 1 2019

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Precision Medicine
Pathology
Neoplasms
Translational Medical Research
Accreditation
Patient Safety
Biomedical Research
Patient Care
Guidelines
Breast Neoplasms
Delivery of Health Care
Therapeutics
Pathologists

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Preanalytics and precision pathology : Pathology practices to ensure molecular integrity of cancer patient biospecimens for precision medicine. / Compton, Carolyn C.; Robb, James A.; Anderson, Matthew W.; Berry, Anna B.; Birdsong, George G.; Bloom, Kenneth J.; Branton, Philip A.; Crothers, Jessica W.; Cushman-Vokoun, Allison M.; Hicks, David G.; Khoury, Joseph D.; Laser, Jordan; Marshall, Carrie B.; Misialek, Michael J.; Natale, Kristen E.; Nowak, Jan Anthony; Olson, Damon; Pfeifer, John D.; Schade, Andrew; Vance, Gail H.; Walk, Eric E.; Yohe, Sophia Louise.

In: Archives of Pathology and Laboratory Medicine, Vol. 143, No. 11, 01.01.2019, p. 1346-1363.

Research output: Contribution to journalReview article

Compton, CC, Robb, JA, Anderson, MW, Berry, AB, Birdsong, GG, Bloom, KJ, Branton, PA, Crothers, JW, Cushman-Vokoun, AM, Hicks, DG, Khoury, JD, Laser, J, Marshall, CB, Misialek, MJ, Natale, KE, Nowak, JA, Olson, D, Pfeifer, JD, Schade, A, Vance, GH, Walk, EE & Yohe, SL 2019, 'Preanalytics and precision pathology: Pathology practices to ensure molecular integrity of cancer patient biospecimens for precision medicine', Archives of Pathology and Laboratory Medicine, vol. 143, no. 11, pp. 1346-1363. https://doi.org/10.5858/arpa.2019-0009-SA
Compton, Carolyn C. ; Robb, James A. ; Anderson, Matthew W. ; Berry, Anna B. ; Birdsong, George G. ; Bloom, Kenneth J. ; Branton, Philip A. ; Crothers, Jessica W. ; Cushman-Vokoun, Allison M. ; Hicks, David G. ; Khoury, Joseph D. ; Laser, Jordan ; Marshall, Carrie B. ; Misialek, Michael J. ; Natale, Kristen E. ; Nowak, Jan Anthony ; Olson, Damon ; Pfeifer, John D. ; Schade, Andrew ; Vance, Gail H. ; Walk, Eric E. ; Yohe, Sophia Louise. / Preanalytics and precision pathology : Pathology practices to ensure molecular integrity of cancer patient biospecimens for precision medicine. In: Archives of Pathology and Laboratory Medicine. 2019 ; Vol. 143, No. 11. pp. 1346-1363.
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AU - Berry, Anna B.

AU - Birdsong, George G.

AU - Bloom, Kenneth J.

AU - Branton, Philip A.

AU - Crothers, Jessica W.

AU - Cushman-Vokoun, Allison M.

AU - Hicks, David G.

AU - Khoury, Joseph D.

AU - Laser, Jordan

AU - Marshall, Carrie B.

AU - Misialek, Michael J.

AU - Natale, Kristen E.

AU - Nowak, Jan Anthony

AU - Olson, Damon

AU - Pfeifer, John D.

AU - Schade, Andrew

AU - Vance, Gail H.

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