Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis

Kirsten I. Bos, Kelly M. Harkins, Alexander Herbig, Mireia Coscolla, Nico Weber, Iñaki Comas, Stephen A. Forrest, Josephine M. Bryant, Simon R. Harris, Verena J. Schuenemann, Tessa J. Campbell, Kerttu Majander, Alicia K. Wilbur, Ricardo A. Guichon, Dawnie L. Wolfe Steadman, Della C ollins Cook, Stefan Niemann, Marcel A. Behr, Martin Zumarraga, Ricardo BastidaDaniel Huson, Kay Nieselt, Douglas Young, Julian Parkhill, Jane Buikstra, Sebastien Gagneux, Anne Stone, Johannes Krause

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.

Original languageEnglish (US)
Pages (from-to)494-497
Number of pages4
JournalNature
Volume514
Issue number7523
DOIs
StatePublished - Oct 23 2014

Fingerprint

Tuberculosis
Mycobacterium tuberculosis
Genome
Oceans and Seas
Sea Lions
Human Genome
Genomics
Skeleton
Calibration
Mammals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bos, K. I., Harkins, K. M., Herbig, A., Coscolla, M., Weber, N., Comas, I., ... Krause, J. (2014). Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis. Nature, 514(7523), 494-497. https://doi.org/10.1038/nature13591

Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis. / Bos, Kirsten I.; Harkins, Kelly M.; Herbig, Alexander; Coscolla, Mireia; Weber, Nico; Comas, Iñaki; Forrest, Stephen A.; Bryant, Josephine M.; Harris, Simon R.; Schuenemann, Verena J.; Campbell, Tessa J.; Majander, Kerttu; Wilbur, Alicia K.; Guichon, Ricardo A.; Wolfe Steadman, Dawnie L.; Cook, Della C ollins; Niemann, Stefan; Behr, Marcel A.; Zumarraga, Martin; Bastida, Ricardo; Huson, Daniel; Nieselt, Kay; Young, Douglas; Parkhill, Julian; Buikstra, Jane; Gagneux, Sebastien; Stone, Anne; Krause, Johannes.

In: Nature, Vol. 514, No. 7523, 23.10.2014, p. 494-497.

Research output: Contribution to journalArticle

Bos, KI, Harkins, KM, Herbig, A, Coscolla, M, Weber, N, Comas, I, Forrest, SA, Bryant, JM, Harris, SR, Schuenemann, VJ, Campbell, TJ, Majander, K, Wilbur, AK, Guichon, RA, Wolfe Steadman, DL, Cook, DCO, Niemann, S, Behr, MA, Zumarraga, M, Bastida, R, Huson, D, Nieselt, K, Young, D, Parkhill, J, Buikstra, J, Gagneux, S, Stone, A & Krause, J 2014, 'Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis', Nature, vol. 514, no. 7523, pp. 494-497. https://doi.org/10.1038/nature13591
Bos KI, Harkins KM, Herbig A, Coscolla M, Weber N, Comas I et al. Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis. Nature. 2014 Oct 23;514(7523):494-497. https://doi.org/10.1038/nature13591
Bos, Kirsten I. ; Harkins, Kelly M. ; Herbig, Alexander ; Coscolla, Mireia ; Weber, Nico ; Comas, Iñaki ; Forrest, Stephen A. ; Bryant, Josephine M. ; Harris, Simon R. ; Schuenemann, Verena J. ; Campbell, Tessa J. ; Majander, Kerttu ; Wilbur, Alicia K. ; Guichon, Ricardo A. ; Wolfe Steadman, Dawnie L. ; Cook, Della C ollins ; Niemann, Stefan ; Behr, Marcel A. ; Zumarraga, Martin ; Bastida, Ricardo ; Huson, Daniel ; Nieselt, Kay ; Young, Douglas ; Parkhill, Julian ; Buikstra, Jane ; Gagneux, Sebastien ; Stone, Anne ; Krause, Johannes. / Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis. In: Nature. 2014 ; Vol. 514, No. 7523. pp. 494-497.
@article{662fab8df12347c99bb1240fc4f87f49,
title = "Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis",
abstract = "Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.",
author = "Bos, {Kirsten I.} and Harkins, {Kelly M.} and Alexander Herbig and Mireia Coscolla and Nico Weber and I{\~n}aki Comas and Forrest, {Stephen A.} and Bryant, {Josephine M.} and Harris, {Simon R.} and Schuenemann, {Verena J.} and Campbell, {Tessa J.} and Kerttu Majander and Wilbur, {Alicia K.} and Guichon, {Ricardo A.} and {Wolfe Steadman}, {Dawnie L.} and Cook, {Della C ollins} and Stefan Niemann and Behr, {Marcel A.} and Martin Zumarraga and Ricardo Bastida and Daniel Huson and Kay Nieselt and Douglas Young and Julian Parkhill and Jane Buikstra and Sebastien Gagneux and Anne Stone and Johannes Krause",
year = "2014",
month = "10",
day = "23",
doi = "10.1038/nature13591",
language = "English (US)",
volume = "514",
pages = "494--497",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7523",

}

TY - JOUR

T1 - Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis

AU - Bos, Kirsten I.

AU - Harkins, Kelly M.

AU - Herbig, Alexander

AU - Coscolla, Mireia

AU - Weber, Nico

AU - Comas, Iñaki

AU - Forrest, Stephen A.

AU - Bryant, Josephine M.

AU - Harris, Simon R.

AU - Schuenemann, Verena J.

AU - Campbell, Tessa J.

AU - Majander, Kerttu

AU - Wilbur, Alicia K.

AU - Guichon, Ricardo A.

AU - Wolfe Steadman, Dawnie L.

AU - Cook, Della C ollins

AU - Niemann, Stefan

AU - Behr, Marcel A.

AU - Zumarraga, Martin

AU - Bastida, Ricardo

AU - Huson, Daniel

AU - Nieselt, Kay

AU - Young, Douglas

AU - Parkhill, Julian

AU - Buikstra, Jane

AU - Gagneux, Sebastien

AU - Stone, Anne

AU - Krause, Johannes

PY - 2014/10/23

Y1 - 2014/10/23

N2 - Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.

AB - Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.

UR - http://www.scopus.com/inward/record.url?scp=84911892466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911892466&partnerID=8YFLogxK

U2 - 10.1038/nature13591

DO - 10.1038/nature13591

M3 - Article

C2 - 25141181

AN - SCOPUS:84911892466

VL - 514

SP - 494

EP - 497

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7523

ER -