Potential peripheral biomarkers for the diagnosis of Alzheimer's disease

Seema Patel, Raj J. Shah, Paul Coleman, Marwan Sabbagh

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Advances in the discovery of a peripheral biomarker for the diagnosis of Alzheimer's would provide a way to better detect the onset of this debilitating disease in a manner that is both noninvasive and universally available. This paper examines the current approaches that are being used to discover potential biomarker candidates available in the periphery. The search for a peripheral biomarker that could be utilized diagnostically has resulted in an extensive amount of studies that employ several biological approaches, including the assessment of tissues, genomics, proteomics, epigenetics, and metabolomics. Although a definitive biomarker has yet to be confirmed, advances in the understanding of the mechanisms of the disease and major susceptibility factors have been uncovered and reveal promising possibilities for the future discovery of a useful biomarker.

Original languageEnglish (US)
Article number572495
JournalInternational Journal of Alzheimer's Disease
DOIs
StatePublished - Dec 1 2011
Externally publishedYes

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Alzheimer Disease
Biomarkers
Metabolomics
Disease Susceptibility
Genomics
Epigenomics
Proteomics

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Aging
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Potential peripheral biomarkers for the diagnosis of Alzheimer's disease. / Patel, Seema; Shah, Raj J.; Coleman, Paul; Sabbagh, Marwan.

In: International Journal of Alzheimer's Disease, 01.12.2011.

Research output: Contribution to journalReview article

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