TY - JOUR
T1 - Potential Diagnostic and Prognostic Biomarkers of Epigenetic Drift within the Cardiovascular Compartment
AU - Wallace, Robert G.
AU - Twomey, Laura C.
AU - Custaud, Marc Antoine
AU - Moyna, Niall
AU - Cummins, Philip M.
AU - Mangone, Marco
AU - Murphy, Ronan P.
N1 - Funding Information:
Dr. Ronan Murphy is a Management Committee Member of the EU H2020 COST Action, CM1406, EpiChemBio. Robert G. Wallace and Laura C. Twomey are joint first authors. The authors would like to acknowledge financial support provided through the Irish Higher Education Authority Programme for Research in Third Level Institutes (HEA-PRTLI Cycle 4: T3 Targeted Therapeutics and Theranostics) (to P. M. Cummins and R. P. Murphy), the Health Research Board of Ireland (HRB- RP/2005/184, HRA/2009/122, and HRA/2009/122/R), Science Foundation Ireland (SFI-04/BR/B0577, 11/TIDA/B1927), Enterprise Ireland (EI- PC/2009/0311) (to R. P. Murphy), Irish Research Council (RS/2011/695, RS/2012/2499) (to R. G. Wallace, L. C. Twomey, and R. P. Murphy), and the Arizona State University and Dublin City University Collaborative Support Award (to M. Mangone and R. P. Murphy).
Publisher Copyright:
© 2016 Robert G. Wallace et al.
PY - 2016
Y1 - 2016
N2 - Biomarkers encompass a wide range of different measurable indicators, representing a tangible link to physiological changes occurring within the body. Accessibility, sensitivity, and specificity are significant factors in biomarker suitability. New biomarkers continue to be discovered, and questions over appropriate selection and assessment of their usefulness remain. If traditional markers of inflammation are not sufficiently robust in their specificity, then perhaps alternative means of detection may provide more information. Epigenetic drift (epigenetic modifications as they occur as a direct function with age), and its ancillary elements, including platelets, secreted microvesicles (MVs), and microRNA (miRNA), may hold enormous predictive potential. The majority of epigenetic drift observed in blood is independent of variations in blood cell composition, addressing concerns affecting traditional blood-based biomarker efficacy. MVs are found in plasma and other biological fluids in healthy individuals. Altered MV/miRNA profiles may also be found in individuals with various diseases. Platelets are also highly reflective of physiological and lifestyle changes, making them extremely sensitive biomarkers of human health. Platelets release increased levels of MVs in response to various stimuli and under a plethora of disease states, which demonstrate a functional effect on other cell types.
AB - Biomarkers encompass a wide range of different measurable indicators, representing a tangible link to physiological changes occurring within the body. Accessibility, sensitivity, and specificity are significant factors in biomarker suitability. New biomarkers continue to be discovered, and questions over appropriate selection and assessment of their usefulness remain. If traditional markers of inflammation are not sufficiently robust in their specificity, then perhaps alternative means of detection may provide more information. Epigenetic drift (epigenetic modifications as they occur as a direct function with age), and its ancillary elements, including platelets, secreted microvesicles (MVs), and microRNA (miRNA), may hold enormous predictive potential. The majority of epigenetic drift observed in blood is independent of variations in blood cell composition, addressing concerns affecting traditional blood-based biomarker efficacy. MVs are found in plasma and other biological fluids in healthy individuals. Altered MV/miRNA profiles may also be found in individuals with various diseases. Platelets are also highly reflective of physiological and lifestyle changes, making them extremely sensitive biomarkers of human health. Platelets release increased levels of MVs in response to various stimuli and under a plethora of disease states, which demonstrate a functional effect on other cell types.
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U2 - 10.1155/2016/2465763
DO - 10.1155/2016/2465763
M3 - Review article
C2 - 26942189
AN - SCOPUS:84958069026
SN - 2314-6133
VL - 2016
JO - BioMed Research International
JF - BioMed Research International
M1 - 2465763
ER -