Positive or negative allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) does not alter expression of behavioral sensitization to methamphetamine

Peter R. Kufahl, Natali E. Nemirovsky, Lucas R. Watterson, Nicholas Zautra, Michael Olive

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We investigated the role of metabotropic glutamate receptor type 5 (mGluR5) in methamphetamine-induced behavioral sensitization. The mGluR5 positive allosteric modulator (3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamide (CDPPB) and negative allosteric modulator fenobam were tested in separate experiments. Sprague-Dawley rats were repeatedly injected with 1 mg/kg methamphetamine or saline, and then given a locomotor challenge test using a dose of 0.5 mg/kg methamphetamine. Prior to the challenge test session, rats were injected with CDPPB, fenobam, or a vehicle. Doses from previous studies showed reduced drug-conditioned behavior; however in this study neither CDPPB nor fenobam pretreatment resulted in an altered expression of behavioral sensitization, indicating a lack of mGluR5 involvement in sensitized methamphetamine-induced locomotion. Additionally, the high dose (30 mg/kg) of fenobam resulted in decreased methamphetamine-induced locomotion in rats regardless of drug exposure history, which suggests evidence of nonspecific behavioral inhibition.

Original languageEnglish (US)
Article number84.v1
JournalF1000Research
Volume2
DOIs
StatePublished - Mar 12 2013

Fingerprint

Metabotropic Glutamate 5 Receptor
Methamphetamine
Modulation
Rats
Locomotion
Modulators
Pharmaceutical Preparations
Sprague Dawley Rats
History
3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
fenobam
Experiments

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Positive or negative allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) does not alter expression of behavioral sensitization to methamphetamine. / Kufahl, Peter R.; Nemirovsky, Natali E.; Watterson, Lucas R.; Zautra, Nicholas; Olive, Michael.

In: F1000Research, Vol. 2, 84.v1, 12.03.2013.

Research output: Contribution to journalArticle

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