Population proteomics

The concept, attributes, and potential for cancer biomarker research

Dobrin Nedelkov, Urban A. Kiernan, Eric E. Niederkofler, Kemmons A. Tubbs, Randall W. Nelson

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

This review outlines the concept of population proteomics and its implication in the discovery and validation of cancer-specific protein modulations. Population proteomics is an applied subdiscipline of proteomics engaging in the investigation of human proteins across and within populations to define and better understand protein diversity. Population proteomics focuses on interrogation of specific proteins from large number of individuals, utilizing top-down, targeted affinity mass spectrometry approaches to probe protein modifications. Deglycosylation, sequence truncations, side-chain residue modifications, and other modifications have been reported for myriad of proteins, yet little is know about their incidence rate in the general population. Such information can be gathered via population proteomics and would greatly aid the biomarker discovery efforts. Discovery of novel protein modifications is also expected from such large scale population proteomics, expanding the protein knowledge database. In regard to cancer protein biomarkers, their validation via population proteomics-based approaches is advantageous as mass spectrometry detection is used both in the discovery and validation process, which is essential for the detection of those structurally modified protein biomarkers.

Original languageEnglish (US)
Pages (from-to)1811-1818
Number of pages8
JournalMolecular and Cellular Proteomics
Volume5
Issue number10
DOIs
StatePublished - Oct 2006

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Tumor Biomarkers
Proteomics
Research
Population
Proteins
Biomarkers
Mass Spectrometry
Mass spectrometry
Protein Databases
Modulation
Incidence

ASJC Scopus subject areas

  • Biochemistry

Cite this

Nedelkov, D., Kiernan, U. A., Niederkofler, E. E., Tubbs, K. A., & Nelson, R. W. (2006). Population proteomics: The concept, attributes, and potential for cancer biomarker research. Molecular and Cellular Proteomics, 5(10), 1811-1818. https://doi.org/10.1074/mcp.R600006-MCP200

Population proteomics : The concept, attributes, and potential for cancer biomarker research. / Nedelkov, Dobrin; Kiernan, Urban A.; Niederkofler, Eric E.; Tubbs, Kemmons A.; Nelson, Randall W.

In: Molecular and Cellular Proteomics, Vol. 5, No. 10, 10.2006, p. 1811-1818.

Research output: Contribution to journalArticle

Nedelkov, Dobrin ; Kiernan, Urban A. ; Niederkofler, Eric E. ; Tubbs, Kemmons A. ; Nelson, Randall W. / Population proteomics : The concept, attributes, and potential for cancer biomarker research. In: Molecular and Cellular Proteomics. 2006 ; Vol. 5, No. 10. pp. 1811-1818.
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