Population Genetics of the Washington National Primate Research Center's (WaNPRC) Captive Pigtailed Macaque (Macaca nemestrina) Population

Sreetharan Kanthaswamy, Jillian Ng, Maria Cecilia T Penedo, Thea Ward, David Glenn Smith, James C. Ha

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Pigtailed macaques (Macaca nemestrina) provide an important model for biomedical research on human disease and for studying the evolution of primate behavior. The genetic structure of captive populations of pigtailed macaques is not as well described as that of captive rhesus (M. mulatta) or cynomolgus (M. fascicularis) macaques. The Washington National Primate Research Center houses the largest captive colony of pigtailed macaques located in several different housing facilities. Based on genotypes of 18 microsatellite (short tandem repeat [STR]) loci, these pigtailed macaques are more genetically diverse than captive rhesus macaques and exhibit relatively low levels of inbreeding. Colony genetic management facilitates the maintenance of genetic variability without compromising production goals of a breeding facility. The periodic introduction of new founders from specific sources to separate housing facilities at different times influenced the colony's genetic structure over time and space markedly but did not alter its genetic diversity significantly. Changes in genetic structure over time were predominantly due to the inclusion of animals from the Yerkes National Primate Research Center in the original colony and after 2005. Strategies to equalize founder representation in the colony have maximized the representation of the founders' genomes in the extant population. Were exchange of animals among the facilities increased, further differentiation could be avoided. The use of highly differentiated animals may confound interpretations of phenotypic differences due to the inflation of the genetic contribution to phenotypic variance of heritable traits.

Original languageEnglish (US)
Pages (from-to)1017-1027
Number of pages11
JournalAmerican Journal of Primatology
Volume74
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

Macaca nemestrina
primate
population genetics
Primates
genetic structure
animal
microsatellite repeats
captive population
animals
genetic variation
inflation
biomedical research
inbreeding
Macaca mulatta
human diseases
Macaca
phenotypic variation
space and time
genotype
genome

Keywords

  • Captive populations
  • Closed colony
  • Genetic management
  • Population genetic structure

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Population Genetics of the Washington National Primate Research Center's (WaNPRC) Captive Pigtailed Macaque (Macaca nemestrina) Population. / Kanthaswamy, Sreetharan; Ng, Jillian; Penedo, Maria Cecilia T; Ward, Thea; Smith, David Glenn; Ha, James C.

In: American Journal of Primatology, Vol. 74, No. 11, 11.2012, p. 1017-1027.

Research output: Contribution to journalArticle

Kanthaswamy, Sreetharan ; Ng, Jillian ; Penedo, Maria Cecilia T ; Ward, Thea ; Smith, David Glenn ; Ha, James C. / Population Genetics of the Washington National Primate Research Center's (WaNPRC) Captive Pigtailed Macaque (Macaca nemestrina) Population. In: American Journal of Primatology. 2012 ; Vol. 74, No. 11. pp. 1017-1027.
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