Population genetic structure of traditional populations in the peruvian central andes and implications for South American population history

Graciela S. Cabana, Cecil M. Lewis, Raúl Y. Tito, R. Alan Covey, Angela M. Cáceres, Augusto F. De La Cruz, Diana Durand, Genevieve Housman, Brannon I. Hulsey, Gian Carlo Iannacone, Paul W. López, Rolando Martínez, Ángel Medina, Olimpio Ortega Dávila, Karla Paloma Osorio Pinto, Susan I Polo Santillán, Percy Rojas Domínguez, Meagan Rubel, Heather F. Smith, Silvia E. SmithVerónica Rubín De Celis Massa, Beatriz Lizárraga, Anne Stone

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Molecular-based characterizations of Andean peoples are traditionally conducted in the service of elucidating continent-level evolutionary processes in South America. Consequently, genetic variation among “western” Andean populations is often represented in relation to variation among “eastern” Amazon and Orinoco River Basin populations. This west-east contrast in patterns of population genetic variation is typically attributed to large-scale phenomena, such as dual founder colonization events or difffering long-term microevolutionary histories. However, alternative explanations that consider the nature and causes of population genetic diversity within the Andean region remain underexplored. Here we examine population genetic diversity in the Peruvian Central Andes using data from the mtDNA fijirst hypervariable region and Y-chromosome short tandem repeats among 17 newly sampled populations and 15 published samples. Using this geographically comprehensive data set, we fijirst reassessed the currently accepted pattern of western versus eastern population genetic structure, which our results ultimately reject: mtDNA population diversities were lower, rather than higher, within Andean versus eastern populations, and only highland Y-chromosomes exhibited signifijicantly higher within-population diversities.

Original languageEnglish (US)
Pages (from-to)147-165
Number of pages19
JournalHuman biology
Volume86
Issue number3
DOIs
StatePublished - Jan 1 2014

Keywords

  • Amazonian populations
  • Andean populations
  • Mtdna
  • Native americans
  • Peopling of South America
  • Peru
  • Y-chromosome

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

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    Cabana, G. S., Lewis, C. M., Tito, R. Y., Alan Covey, R., Cáceres, A. M., De La Cruz, A. F., Durand, D., Housman, G., Hulsey, B. I., Iannacone, G. C., López, P. W., Martínez, R., Medina, Á., Dávila, O. O., Pinto, K. P. O., Santillán, S. I. P., Domínguez, P. R., Rubel, M., Smith, H. F., ... Stone, A. (2014). Population genetic structure of traditional populations in the peruvian central andes and implications for South American population history. Human biology, 86(3), 147-165. https://doi.org/10.13110/humanbiology.86.3.0147