Polyploidy, aneuploidy and the evolution of cancer

Lauren M F Merlo, Li San Wang, John W. Pepper, Peter S. Rabinovitch, Carlo Maley

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Citations (Scopus)

Abstract

Aneuploidy is a ubiquitous feature of cancer and pre-cancerous lesions, yet its significance is poorly characterized. In this chapter, we review the role of tetraploidy and aneuploidy in progression. We examine how aneuploidy may contribute to the evolutionary dynamics prevalent in neoplastic progression, considering whether aneuploidy itself is selectively neutral or advantageous or if it simply acts as a mechanism for the more rapid accumulation of mutations increasing survival and reproduction of cancer cells. We also review evidence from Barrett's esophagus, a pre-malignant condition, demonstrating that tetraploidy and aneuploidy are correlated with an increased risk of progression to cancer. Ultimately, we aim provide testable hypotheses and methods for understanding the role of aneuploidy in cancer.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages1-13
Number of pages13
Volume675
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume675
ISSN (Print)00652598

Fingerprint

Polyploidy
Aneuploidy
Neoplasms
Tetraploidy
Cells
Barrett Esophagus
Reproduction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Merlo, L. M. F., Wang, L. S., Pepper, J. W., Rabinovitch, P. S., & Maley, C. (2010). Polyploidy, aneuploidy and the evolution of cancer. In Advances in Experimental Medicine and Biology (Vol. 675, pp. 1-13). (Advances in Experimental Medicine and Biology; Vol. 675). https://doi.org/10.1007/978-1-4419-6199-0_1

Polyploidy, aneuploidy and the evolution of cancer. / Merlo, Lauren M F; Wang, Li San; Pepper, John W.; Rabinovitch, Peter S.; Maley, Carlo.

Advances in Experimental Medicine and Biology. Vol. 675 2010. p. 1-13 (Advances in Experimental Medicine and Biology; Vol. 675).

Research output: Chapter in Book/Report/Conference proceedingChapter

Merlo, LMF, Wang, LS, Pepper, JW, Rabinovitch, PS & Maley, C 2010, Polyploidy, aneuploidy and the evolution of cancer. in Advances in Experimental Medicine and Biology. vol. 675, Advances in Experimental Medicine and Biology, vol. 675, pp. 1-13. https://doi.org/10.1007/978-1-4419-6199-0_1
Merlo LMF, Wang LS, Pepper JW, Rabinovitch PS, Maley C. Polyploidy, aneuploidy and the evolution of cancer. In Advances in Experimental Medicine and Biology. Vol. 675. 2010. p. 1-13. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-6199-0_1
Merlo, Lauren M F ; Wang, Li San ; Pepper, John W. ; Rabinovitch, Peter S. ; Maley, Carlo. / Polyploidy, aneuploidy and the evolution of cancer. Advances in Experimental Medicine and Biology. Vol. 675 2010. pp. 1-13 (Advances in Experimental Medicine and Biology).
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