TY - CHAP
T1 - Polyploidy, aneuploidy and the evolution of cancer
AU - Merlo, Lauren M.F.
AU - Wang, Li San
AU - Pepper, John W.
AU - Rabinovitch, Peter S.
AU - Maley, Carlo C.
PY - 2010
Y1 - 2010
N2 - Aneuploidy is a ubiquitous feature of cancer and pre-cancerous lesions, yet its significance is poorly characterized. In this chapter, we review the role of tetraploidy and aneuploidy in progression. We examine how aneuploidy may contribute to the evolutionary dynamics prevalent in neoplastic progression, considering whether aneuploidy itself is selectively neutral or advantageous or if it simply acts as a mechanism for the more rapid accumulation of mutations increasing survival and reproduction of cancer cells. We also review evidence from Barrett's esophagus, a pre-malignant condition, demonstrating that tetraploidy and aneuploidy are correlated with an increased risk of progression to cancer. Ultimately, we aim provide testable hypotheses and methods for understanding the role of aneuploidy in cancer.
AB - Aneuploidy is a ubiquitous feature of cancer and pre-cancerous lesions, yet its significance is poorly characterized. In this chapter, we review the role of tetraploidy and aneuploidy in progression. We examine how aneuploidy may contribute to the evolutionary dynamics prevalent in neoplastic progression, considering whether aneuploidy itself is selectively neutral or advantageous or if it simply acts as a mechanism for the more rapid accumulation of mutations increasing survival and reproduction of cancer cells. We also review evidence from Barrett's esophagus, a pre-malignant condition, demonstrating that tetraploidy and aneuploidy are correlated with an increased risk of progression to cancer. Ultimately, we aim provide testable hypotheses and methods for understanding the role of aneuploidy in cancer.
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U2 - 10.1007/978-1-4419-6199-0_1
DO - 10.1007/978-1-4419-6199-0_1
M3 - Chapter
C2 - 20687466
AN - SCOPUS:77955856948
SN - 9781441961983
T3 - Advances in Experimental Medicine and Biology
SP - 1
EP - 13
BT - Polyploidization and Cancer
A2 - Poon, Randy
ER -