Poly(N-isopropylacrylamide-co-poly(ethylene glycol))-acrylate simultaneously physically and chemically gelling polymer systems

Vicki Cheng, Bae Hoon Lee, Christine Pauken, Brent Vernon

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

In an effort to create an in situ physically and chemically cross-linked hydrogel for in vivo applications, N-isopropylacrylamide (NIPAAm) was copolymerized with poly(ethylene glycol)-monoacrylate (PEG-monoacrylate) and then the hydroxyl terminus of the PEG was further modified with acryloyl chloride to form poly(NIPAAm-co-PEG) with acrylate terminated pendant groups. In addition to physically gelling with temperature changes, when mixed with a multi-thiol compound such as pentaerythritol tetrakis 3-mercaptopropionate (QT) in phosphate buffer saline solution of pH 7.4, this polymer formed a chemical gel via a Michael-type addition reaction. The chemical gelation time of the polymer was affected by mixing time; swelling of the copolymer solutions was temperature dependant. Because of its unique gelation properties, this material may be better suited for long-term functional replacement applications than other thermo-sensitive physical gels. Also, the PEG content of this material may render it more biocompatible than similar HEMA-based precursors in previous simultaneous chemically and physically gelling materials. With its improved mechanical strength and biocompatibility, this material could potentially be applied as a thermally gelling injectable biomaterial for aneurysm or arteriovenous malformation (AVM) occlusion.

Original languageEnglish (US)
Pages (from-to)1201-1207
Number of pages7
JournalJournal of Applied Polymer Science
Volume106
Issue number2
DOIs
StatePublished - Oct 15 2007

Keywords

  • Cross-linking
  • Hydrogels
  • Injectable biomaterials
  • Michael-type addition
  • Stimuli-sensitive polymers

ASJC Scopus subject areas

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

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