TY - GEN
T1 - Polymer-based sensors for dynamic intravascular shear stress analysis
AU - Ai, Lisong
AU - Yu, Hongyu
AU - Rouhanizadeh, Mahsa
AU - Takabe, Wakako
AU - Meng, Ellis
AU - Kim, E. S.
AU - Hsiai, Tzung
PY - 2008
Y1 - 2008
N2 - This paper describes a polymer-based shear stress sensor built on catheter for in vivo measurements and potential application in atherosclerosis diagnosis. MEMS shear stress sensor with backside wire bonding has been used to address in vitro applications for micro-scale hemodynamics with high temporal and spatial resolution. However, to assess shear stress in the tortuous and dynamic arterial circulation, we had to develop a new generation of polymer- and catheter-based sensors that are both flexible and deployable. The individual sensor was packaged near the tip of a catheter for intravascular shear stress analysis. The wire bonding and electrode leads were insulated by a film of Parylene C and were connected to the external circuit along the guide-wire. The sensor was deployed through the catheter into the aorta of New Zealand White (NZW) rabbits by the femoral cut-down procedure. Based on the heat transfer principle, the device was able to detect small temperature perturbation in response to the pulsatile flow at ̃ 200 beats/minutes in the rabbits. The sensor was calibrated in the presence of rabbit blood flow at 37.8°C. We demonstrated the feasibility of translating a polymer- based device for dynamic intravascular measurement with a potential for clinical applications in detecting coronary artery disease and stroke.
AB - This paper describes a polymer-based shear stress sensor built on catheter for in vivo measurements and potential application in atherosclerosis diagnosis. MEMS shear stress sensor with backside wire bonding has been used to address in vitro applications for micro-scale hemodynamics with high temporal and spatial resolution. However, to assess shear stress in the tortuous and dynamic arterial circulation, we had to develop a new generation of polymer- and catheter-based sensors that are both flexible and deployable. The individual sensor was packaged near the tip of a catheter for intravascular shear stress analysis. The wire bonding and electrode leads were insulated by a film of Parylene C and were connected to the external circuit along the guide-wire. The sensor was deployed through the catheter into the aorta of New Zealand White (NZW) rabbits by the femoral cut-down procedure. Based on the heat transfer principle, the device was able to detect small temperature perturbation in response to the pulsatile flow at ̃ 200 beats/minutes in the rabbits. The sensor was calibrated in the presence of rabbit blood flow at 37.8°C. We demonstrated the feasibility of translating a polymer- based device for dynamic intravascular measurement with a potential for clinical applications in detecting coronary artery disease and stroke.
UR - http://www.scopus.com/inward/record.url?scp=70349142250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349142250&partnerID=8YFLogxK
U2 - 10.1115/biomed2008-38097
DO - 10.1115/biomed2008-38097
M3 - Conference contribution
AN - SCOPUS:70349142250
SN - 0791848337
SN - 9780791848333
T3 - 2008 Proceedings of the 3rd Frontiers in Biomedical Devices Conference and Exhibition
SP - 55
EP - 57
BT - 2008 Proceedings of the 3rd Frontiers in Biomedical Devices Conference and Exhibition
PB - ASME
T2 - 2008 3rd Frontiers in Biomedical Devices Conference and Exhibition
Y2 - 18 June 2008 through 20 June 2008
ER -